Skip to main content
SpringerLink
Log in

Lymphocyte-Mediated Natural Cytotoxicity to HPV16 Infected Cervical Keratinocytes

  • Chapter
Immunology of Human Papillomaviruses

  • 71 Accesses

Abstract

Natural. Killer (NK) cells are capable of mediating spontaneous antibody-independent and non-MHC restricted cytotoxicity against many human neoplastic and virally infected cells without prior sensitization1. The activity of NK cells can be augmented by several. cytokines. Purified IL-2 (Interleukin-2) alone is able to cause direct activation of nonlytic PBLs (Peripheral. blood lymphocytes) into LAK (Lymphokine Activated Killer) cells without known antigen stimuli in vitro2. LAK are capable of binding to and killing a broad range of neoplastic and normal. tissues (both NK-sensitive and NK-resistant)3,4. iFNγ can also influence the immune response by modulating susceptibilility of targets 5.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Santoli, G. Trinchieri, and F.S. Lief: Cell-mediated cytotoxicity against virus-infected target cells in human. J Immunol 121:526 (1978)

    PubMed  CAS  Google Scholar 

  2. E. A Grimm, RJ. Robb, J. A. Roth, L. M. Neckers, L.B Lachman, DJ. Wilson, and S.A. Rosenberg: Lymphokine-activated killer cell phenomenon. J Exp Med. 158:1356 (1983)

    Article  PubMed  CAS  Google Scholar 

  3. J. H. Phillips and L. L. Lanier: Dissection of the lymphokine-activated killer phenomenon. J Exp Med. l64:814 (1986)

    Article  Google Scholar 

  4. E. A. Grimm, A. Mazumder, H. Z. Zhang, and S. A. Rosenberg: Lymphokine-activated killer cell Phenomenon. J Exp Med 155:1823 (1982)

    Article  PubMed  CAS  Google Scholar 

  5. R. Kurzrock: Interferon-gamma. In‘Cytokine Therapy’, ed D.W Galvani and J.C. Cawley. University of Cambridge. Cambridge (1992)

    Google Scholar 

  6. J.Malejczyk, S.Majewski, SJablonska, T.T.Rogozinski and G. Orth: Abrogated Nk-cell lysis of human papillomavirus(HPV)-16-Bearing keratinocytes in patients with pre-cancerous and cancerous HPV-induced anogenital. lesions. Int J Cancer 43,209 (1989)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK

    Rong Wu, Nicholas Coleman, Geoffrey Higgins, Esther Choolun & Margaret A. Stanley

Authors
  1. Rong Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicholas Coleman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Geoffrey Higgins
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Esther Choolun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Margaret A. Stanley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology, University of Cambridge, Cambridge, UK

    Margaret A. Stanley

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wu, R., Coleman, N., Higgins, G., Choolun, E., Stanley, M.A. (1994). Lymphocyte-Mediated Natural Cytotoxicity to HPV16 Infected Cervical Keratinocytes. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2449-6_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6041-4

  • Online ISBN: 978-1-4615-2449-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation