Abstract
HPV type 16 is commonly associated with human cervical. carcinomas (Crawford, 1993). It has been demonstrated that cell-mediated immunity plays an important role in human host defence against some viral. infections such as herpes viruses and hepatitis B virus (Wildy and Gell, 1985). The link between cellular immunodeficiency and the high incidence of HPV-induced lesions (Kirshner, 1986; Alloub et al., 1989) suggests a possible involvement of lymphocytes in the control of HPV associated diseases. But little is known about CTL response to different virus encoded gene products (Altmann et al., 1992). The expression of virus encoded E7 gene is often observed in biopsies from malignant tissues (Smotkin and Wettstein, 1986; Seedorf et al., 1987) which makes it a good candidate for targeting an immune attack. The aim of the present study was to investigate whether E7 gets access to the MHC class I presentation pathway in H-2b mice and is able to induce a CTL response.
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Sadovnikova, E., Zhu, X., Collins, S.M., Beverley, P., Stauss, H.J. (1994). Murine Cytotoxic T Cell Responses to Human Papillomavirus E7 Protein. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_34
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DOI: https://doi.org/10.1007/978-1-4615-2449-6_34
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