Abstract
Normal human epithelial cells cultured from foreskin or cervical epithelia can be immortalized by a subset of HPV DNAs associated with a high risk of cervical cancer (Pirisi et al., 1987; Woodworth et al., 1989). The HPV-immortalized cell lines exhibit aberrant growth and differentiation when maintained as organotypic cultures (McCance et al., 1988) or in vivo (Woodworth et al., 1990). It is hypothesized that HPV oncoproteins E6 and E7 contribute to immortalization through their ability to bind the products of the tumor suppressor genes p53 and Rb, respectively (Munger et al., 1992).
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Woodworth, C.D., Wang, H., Alvarez-Salas, L.M., DiPaolo, J.A. (1994). Enhanced Production of Wild-Type P53 Inhibits Growth and Differentiation of Normal Foreskin Epithelial Cells but not Cell Lines Containing Human Papillomavirus DNA. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_2
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DOI: https://doi.org/10.1007/978-1-4615-2449-6_2
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