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Steroid Contraceptives and Women’s Response pp 91–102Cite as

Pharmacodynamics of Norplant R Implants

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Part of the book series: Reproductive Biology ((RBIO))

Abstract

NORPLANTR subdermal implants comprise a contraceptive modality in which levonorgestrel is continuously released from capsules placed beneath the skin. The capsules are made of a dimethylsiloxane/methylvinylsiloxane copolymer (SilasticR) and are filled with crystalline levonorgestrel. Each capsule is of 34 mm total length with 30 mm of the length being filled with steroid. The diameter is 2.4 mm. Six capsules are placed in a fan-shaped pattern through a single 3 mm incision. Clinical studies have shown effectiveness through five years.

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References

  1. Weiner, E. and Johansson, E.D.B. Plasma levels of d-norgestrel, estradiol, and progesterone during treatment with Silastic implants containing dnorgestrel. Contraception 14:81–92 (1976).

    Article  PubMed  CAS  Google Scholar 

  2. Stanczyk, F.Z., et al. Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration. Contraception 12:279–298 (1975).

    Article  PubMed  CAS  Google Scholar 

  3. Sivin, I. Unpublished.

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  4. Affandi, B., et al. The interaction between sex hormone binding globulin and levonorgestrel released from NORPLANTR, an implantable contraceptive. Contraception 35:135–144 (1987).

    Article  PubMed  CAS  Google Scholar 

  5. Weiner, E. and Johansson, E.D.B. Contraception with d-norgestrel Silastic rods. Plasma levels of d-norgestrel and influence on the ovarian function. Contraception 14:551–562 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. Hümpel, M., et al. Investigations of the pharmacokinetics of levonorgestrel to specific consideration of a first pass effect. Contraception 17:207–220 (1978).

    Article  PubMed  Google Scholar 

  7. El-Raghy, I., et al. Pharmacokinetics of oral contraceptive steroids in Egyptian women: studies with oral NORDETTE and NORMINST. Contraception 33:379–384 (1986).

    Article  PubMed  CAS  Google Scholar 

  8. Back, D.J., et al. The pharmacokinetics of levonorgestrel and ethynylestradiol in women — Studies with Ovran and Ovranette. Contraception 23:229–239 (1983).

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. The Population Council, Center for Biomedical Research, 1230 York Avenue, New York, NY, 10021, USA

    Harold A. Nash & Dale N. Robertson

Authors
  1. Harold A. Nash
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  2. Dale N. Robertson
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Editor information

Editors and Affiliations

  1. Department of Population and International Health, Harvard School of Public Health, Boston, Massachusetts, 02115, USA

    Rachel Snow

  2. World Health Organization, Geneva 27, 1211, Switzerland

    Peter Hall

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© 1994 Plenum Press, New York

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Nash, H.A., N. Robertson, D. (1994). Pharmacodynamics of Norplant R Implants. In: Snow, R., Hall, P. (eds) Steroid Contraceptives and Women’s Response. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2445-8_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2445-8_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44718-1

  • Online ISBN: 978-1-4615-2445-8

  • eBook Packages: Springer Book Archive

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