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Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 257))

Abstract

From the work in our laboratory and subsequently other laboratories, it has been known for many years that cyclic GMP induces the relaxation of numerous smooth muscle preparations including vascular, airway and intestinal smooth muscle (Katsuki and Murad, 1977; Katsukiet al., 1977; Murad et al., 1978; Muradet al., 1978; Rapaport and Murad, 1983; Murad, 1986). Smooth muscle relaxation was the first physiological function clearly related to cyclic GMP synthesis. The proposed functions of cyclic GMP have expanded considerably since, as briefly discussed below.

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Authors and Affiliations

  1. Abbott Laboratories, Abbott Park, IL, USA

    Ferid Murad, U. Förstermann, M. Nakane, J. Pollock, H. Schmidt, T. Matsumoto, R. Tracey & W. Buechler

  2. Northwestern University, Chicago, IL, USA

    Ferid Murad, U. Förstermann, M. Nakane, J. Pollock, H. Schmidt, T. Matsumoto, R. Tracey & W. Buechler

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  1. Ferid Murad
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  2. U. Förstermann
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  3. M. Nakane
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  4. J. Pollock
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  5. H. Schmidt
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  6. T. Matsumoto
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  7. R. Tracey
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  8. W. Buechler
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Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    John D. Catravas

  2. Washington University Medical School, St. Louis, Missouri, USA

    Allan D. Callow

  3. T Cell Sciences, Inc., Cambridge, Massachusetts, USA

    Una S. Ryan

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Murad, F. et al. (1993). Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_6

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  • DOI: https://doi.org/10.1007/978-1-4615-2437-3_6

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