Hyaluronan Receptors on Human Endothelial Cells - The Effect of Cytokines
Hyaluronan is an extracellular glycosaminoglycan found in most, if not all, mammalian tissues. High levels of hyaluronan have been noted in many avascular tissues, transiently in tissue undergoing remodeling and morphogenesis, and at the periphery of tumors. Also, many pathological or inflammatory situations show local accumulation of hyaluronan eg. psoriasis, bleomycin induced lung damage and artherosclerosis. Hyaluronan is reported to regulate cell proliferation, adhesion, locomotion and differentiation, its effects being dependent on the size and concentration of hyaluronan and the cell type being studied. These effects are, in most cases, mediated by membrane by membrane receptors, such as CD44 or RHAMM.