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Vascular Endothelium pp 55–71Cite as

Coronary Artery and Coronary Artery Bypass Graft Disease: Role of the Endothelium and Vascular Smooth Muscle

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Part of the book series: NATO ASI Series ((NSSA,volume 257))

Abstract

Coronary artery disease and its sequelae, such as myocardial infarction and sudden death, is one of the most important causes of morbidity and mortality in Western countries. The pathophysiology of coronary artery disease is not fully understood, but three main alterations have been delineated: (1) Increased vasoconstrictor responses in the coronary circulation; (2) augmented platelet-vessel wall interaction and (3) proliferative responses in the blood vessel wall leading to narrowing of major epicardial coronary arteries. All three factors work in concert to cause myocardial ischemia and eventually infarction and death.

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Authors and Affiliations

  1. Cardiology Division of Cardiovascular Research, University Hospital, Bern, Switzerland

    Thomas F. Lüscher

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  1. Medical College of Georgia, Augusta, Georgia, USA

    John D. Catravas

  2. Washington University Medical School, St. Louis, Missouri, USA

    Allan D. Callow

  3. T Cell Sciences, Inc., Cambridge, Massachusetts, USA

    Una S. Ryan

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Lüscher, T.F. (1993). Coronary Artery and Coronary Artery Bypass Graft Disease: Role of the Endothelium and Vascular Smooth Muscle. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_5

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