Matrix Metalloproteinases (MMP’s): Role in Atherogenesis and Plaque Fissure

  • W. Hornebeck
  • Y. Legrand
  • J. Chapman
  • M. P. Jacob
  • S. Menaschi
  • G. Flores Delgado
Part of the NATO ASI Series book series (NSSA, volume 257)

Abstract

Matrix metalloproteinases (MMP’s) a group of neutral zinc endopeptidases, have the capacity to completely degrade all extracellular matrix macromolecules and are directly involved in tissue remodelling. Interactions between human platelets and porcine aorta endothelium cells (EC), which induced an EC shape change, also led to the activation of neutral proteinases: a serine proteinase (M.W. 85 kDa) active on casein gels, designated as PECAP (for “platelet endothelial cells activated protease”) and both 70 and 92 kDa Gelatinases (MMP2 and MMP9) two MMP’s which possess elastinolytic activities.

Keywords

Cholesterol Zinc Serine Macromolecule Laminin 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • W. Hornebeck
    • 1
  • Y. Legrand
    • 2
  • J. Chapman
    • 3
  • M. P. Jacob
    • 1
  • S. Menaschi
    • 2
  • G. Flores Delgado
    • 1
  1. 1.URA CNRS 1460University of Paris XIICréteilFrance
  2. 2.INSERM U 353Hõspital St. LouisParisFrance
  3. 3.INSERM U 321Hõspital La Pitié-SalpétrièreParisFrance

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