Abstract
Matrix metalloproteinases (MMP’s) a group of neutral zinc endopeptidases, have the capacity to completely degrade all extracellular matrix macromolecules and are directly involved in tissue remodelling. Interactions between human platelets and porcine aorta endothelium cells (EC), which induced an EC shape change, also led to the activation of neutral proteinases: a serine proteinase (M.W. 85 kDa) active on casein gels, designated as PECAP (for “platelet endothelial cells activated protease”) and both 70 and 92 kDa Gelatinases (MMP2 and MMP9) two MMP’s which possess elastinolytic activities.
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© 1993 Springer Science+Business Media New York
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Hornebeck, W., Legrand, Y., Chapman, J., Jacob, M.P., Menaschi, S., Delgado, G.F. (1993). Matrix Metalloproteinases (MMP’s): Role in Atherogenesis and Plaque Fissure. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_32
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DOI: https://doi.org/10.1007/978-1-4615-2437-3_32
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