Bovine Neutrophils Impair Endothelium-Dependent Responses to Acetylcholine and Noradrenaline in Isolated Mesenteric Arteries

  • Sjef J. De Kimpe
  • Dicky Van Heuven-Nolsen
  • Frans P. Nijkamp
Part of the NATO ASI Series book series (NSSA, volume 257)

Abstract

Several pathological states are associated with neutrophil accumulation and activation. The interaction of neutrophils with blood vessels may be important in the regulation of vascular tone. In the present study, we examined the effect of polymorphonuclear leukocytes (PMN) on the endothelium-dependent relaxation to acetylcholine and on the vasoconstriction evoked by noradrenaline in the bovine isolated mesenteric artery.

Keywords

Superoxide Noradrenaline Acetylcholine Nitroprusside 

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sjef J. De Kimpe
    • 1
  • Dicky Van Heuven-Nolsen
    • 1
  • Frans P. Nijkamp
    • 1
  1. 1.Department of Pharmacology Faculty of PharmacyUniversity of UtrechtUtrechtThe Netherlands

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