Interaction of Malaria-Infected Cells with the Vascular Wall

  • Giorgio Senaldi
  • Fabienne Tacchini-Cottier
  • Georges E. Grau
Part of the NATO ASI Series book series (NSSA, volume 257)


Recent estimations confirm malaria as the most common infectious disease affecting the human species. Worldwide, more than 2 billion people are at risk of infection. About 200 million cases occur every year and approximately 2 million of them result in the death of the patient, especially children in endemic areas (Greenwood et al., 1987). Plasmodium falciparum infection is by far the most severe form of malaria, which accounts for the vast majority of fatal cases. It owes its severity to its frequency of complications (White, 1986) The most dangerous complication is cerebral malaria (CM), which is responsible for about 80% of all fatal cases, although it develops in only 0.5–1% of the episodes of P. falciparum infection. CM is invariably lethal if untreated, and it also kills up to 40% of treated patients. The recovery from CM is occasionally accompanied by permanent, disabling neurological sequelae (Marsh and Greenwood, 1986; Phillips and Warrell, 1986; World Health Organization Malaria Action Program, 1986; Warred 1987).


Plasmodium Falciparum Cerebral Malana Infected Erythrocyte Endothelial Leukocyte Adhesion Molecule Brain Microcirculation 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Giorgio Senaldi
    • 1
  • Fabienne Tacchini-Cottier
    • 1
  • Georges E. Grau
    • 1
  1. 1.WHO-Immunology Research and Training Centre Department of PathologyUmversity of GenevaSwitzerland

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