Experimental Cell Transplantation and Gene Therapy Techniques in the Treatment of Liver Disease

  • Achilles A. Demetriou
  • J. Rozga
  • D. Neuzil
  • M. Holzman
  • D. Griffin
  • Albert D. Moscioni
Part of the NATO ASI Series book series (NSSA, volume 257)

Abstract

Whole organ transplantation remains the only clinically effective method of treating acute and chronic liver failure due to specific genetic and other defects of liver function. However, there are several factors which limit the application of liver transplantation in the treatment of liver insufficiency: high cost, relatively high morbidity and limited organ donor availability. As a result, investigators have attempted to develop alternative methods to treat liver insufficiency due to genetic defects of liver function by using either isolated normal hepatocyte transplantation and/or in vitro and in vivo gene therapy techniques.

Keywords

Catheter Ischemia Albumin Bromide Electrophoresis 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Achilles A. Demetriou
    • 1
  • J. Rozga
    • 1
  • D. Neuzil
    • 1
  • M. Holzman
    • 2
  • D. Griffin
    • 2
  • Albert D. Moscioni
    • 2
  1. 1.Department of SurgeryCedars-Sinai Medical CenterLos AngelesUSA
  2. 2. School of Medicine Department of SurgeryVanderbilt UniversityNashvilleUSA

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