The Cytoskeleton in the Differentiation of Myelin-Forming Cells
The ensheathment of nerve fibres by oligodendrocytes and Schwann cells requires a dramatic change in cell morphology. Not only must these cells extend long processes in order to insulate axons but they must also migrate considerable distances to reach their targets. Since interactions between the cytoskeleton and the plasma membrane are known to control cell shape and movement, the cellular cytoskeleton must play a fundamental role in myelination.
KeywordsGlial Fibrillary Acidic Protein Schwann Cell Intermediate Filament Oligodendrocyte Progenitor Cell BioI
Unable to display preview. Download preview PDF.
- 1.P.M. Wood and R.P. Bunge, The biology of the oligodendrocyte. In “Oligodendroglia”Norton WT ed: Plenum Press, NY pp 1–46, 1984.Google Scholar
- 2.A.L. Gard and S.E. Pfeiffer, Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage: Myelinogenic potential in a defined environment. Development 106: 119–1321989.Google Scholar
- 12.I. Fischer, Konola and E. Cochary, Microtubule associated protein (MAP1B) is present in cultured oligodendrocytes and colocalizes with tubulin. J Neurosci Res 27: 112–124, 1989.Google Scholar
- 14.D. A. Vouyiouklis and P. J. Brophy, Microtubule-Associated Protein MAP1B expression precedes the morphological differentiation of oligodendrocytes. J. Neurosci. Res., (in press).Google Scholar
- 16.M. Osborn and K. Weber, Biology of Disease. Tumour diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab. Invest. 48: 3372–3394, 1983.Google Scholar
- 20.K.H. Fliegner, G.Y. Ching and R.K.H. Liem, The predicted amino acid sequence of a-internexin is that of a novel neuronal intermediate filament protein. EMBO (Eur. Mol.Biol.Organ.) J. 9: 749–755, 1990.Google Scholar
- 25.M.K. Escurat, K. Djabali, C. Huc, F. Landon, C. Bécourt, C. Boitard, F., Gros, and M-M. Portier, Origin of the beta cells of the islets of Langerhans is further questioned by the expression of neuronal intermediate filament proteins, peripherin and NF-L, in the rat insulinoma RIN5F cell line. Dev. Neurosci. 13: 424–432, 1991.PubMedCrossRefGoogle Scholar