Abstract
Myelin basic protein (MBP), a major myelin antigen, is considered a potential target of the immunopathologic process in Multiple Sclerosis (MS). MBP-specific T lymphocytes indeed mediate experimental allergic encephalomyelitis, the animal model of MS. Furthermore in vivo- activated T cell clones reactive to MBP were detected in the peripheral blood of patients, but not of healthy individuals (1). For these reasons the T cell response against this self-antigen is being extensively investigated in patients with MS.
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Ristori, G. et al. (1994). T Lymphocyte Response to Potential Autoantigens in Patients with Multiple Sclerosis. In: Salvati, S. (eds) A Multidisciplinary Approach to Myelin Diseases II. NATO ASI Series, vol 258. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2435-9_26
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DOI: https://doi.org/10.1007/978-1-4615-2435-9_26
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