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The Correlation Between Magnetic Resonance Imaging Abnormalities and other Aspects of Multiple Sclerosis with Particular Emphasis on Therapeutic Trials

  • Donald W. Paty
Part of the NATO ASI Series book series (NSSA, volume 258)

Abstract

Magnetic resonance (MR) has had a major impact on the evaluation of patients with multiple sclerosis (MS). The most obvious area of influence has been on diagnosis. Diagnostically abnormal head scans can be seen in at least 90% of patients with clinically definite MS (CDMS). In addition, even though the spinal cord has been difficult to image in the past, techniques are improving. However, the findings on individual magnetic resonance imaging (MRI) scans do not usually correlate very well with the clinical (neurological) status of the patient, or with the prior clinical course. That lack of correlation should not be a surprise, however, because the same lack of correlation has always existed between the clinical history and pathological findings.

Keywords

Multiple Sclerosis Expand Disability Status Scale Optic Neuritis Magnetic Resonance Imaging Evaluation Magnetic Resonance Imaging Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Young IR; Hall AS; Pallis CA; Bydder GM; Legg NJ; Steiner RE. Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet 1981;2: 1063–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Robertson WD; Li DK; Mayo JR; Fache JS; Paty DW. Assessment of multiple sclerosis lesions by magnetic resonance imaging. Can Assoc Radiol J. 1987 Sep;38(3): 177–82.PubMedGoogle Scholar
  3. 3.
    Miller DH; Ormerod EC; McDonald WI; MacManus DG; Kendall BE; Kinglsey DPE; Moseley IF. The early risk of multiple sclerosis after optic neuritis. J Neurol Neurosurg Psychiatry. 1988;51: 1569–71.PubMedCrossRefGoogle Scholar
  4. 4.
    Lee KH; Hashimoto SA; Hooge J; Kastrukoff LF; Oger J; Li D; Paty DW. MRI in the diagnosis of MS: A prospective 3 year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding and CT. Neurology. 1991;41: 657–660.PubMedCrossRefGoogle Scholar
  5. 5.
    Paty DW; McFarlin DE; McDonald WI. Magnetic resonance imaging and laboratory aids in the diagnosis of multiple sclerosis [editorial]. Ann Neurol. 1991;29: 3–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Fazekas F; Offenbacher H; Fuchs S; Schmidt R; Niederkorn K; Horner S; Lechner H. Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology. 1988; 38(12): 1822–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Miller DH; Newton MR; van der Poel JC; du Boulay EP; Halliday AM; Kendall BE; Johnson G; MacManus DG; Moseley IF; McDonald WI. Magnetic resonsance imaging of the optic nerve in optic neuritis. Neurology. 1988;38: 175–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Youl BD; Turano G; Miller DH; Towell AD; MacMannus DG; Moore SG; Jones SJ; Barrett G; Kendall BE; Moseley IF; Tofts PS; Halliday AM; McDonald WI. The pathophysiology of acute optic neuritis. Brain 1991.114, 2437–2450.PubMedCrossRefGoogle Scholar
  9. 9.
    Stewart WA; Hall LD; Berry K; Paty DW. Correlation between NMR scan and brain slice: Data in multiple sclerosis. Lancet. 1984;2: 412.PubMedCrossRefGoogle Scholar
  10. 10.
    Ormerod IE; Miller DH; McDonald WI; du Boulay EP; Rudge P; Kendall BE; Moseley IF; Johnson G; Tofts PS; Halliday AM; Bronstein AM; Scaravilli F; Harding AE; Barnes D; Zilkha KJ. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. Brain. 1987;110: 1579–1616.PubMedCrossRefGoogle Scholar
  11. 11.
    Newcombe J; Hawkins CP; Henderson CL; Patel HA; Woodroofe MN; Hayes GM; Cuzner ML; MacManus D; du Boulay EP; McDonald WI. Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed post mortem central nervous system tissue. Brain. 1991;114: 1013–23.PubMedCrossRefGoogle Scholar
  12. 12.
    Oger J; Kastrukoff LF; Li DK; Paty DW. Multiple sclerosis: In relapsing patients, immune functions vary with disease as assessed by MRI. Neurology. 1988;38: 1739–44.PubMedCrossRefGoogle Scholar
  13. 13.
    Katz D; Taubenberger J; Raine C; McFarlin D; McFarland H. Gadolinium-enhancing lesions on magentic resonance imaging: Neuropathological findings. Ann Neurol 1990;28: 243.CrossRefGoogle Scholar
  14. 14.
    Paty DW. Multiple sclerosis: Assessment of disease progression and effects of treatment Can J Neurol Sci. 1987;14: 518–520.PubMedGoogle Scholar
  15. 15.
    Koopmans R; Li DK; Grochowski E; Cutler P; Paty DW. Benign versus chronic progressive multiple sclerosis: Magnetic resonance imaging features. Ann Neurol. 1989;25: 74–81.PubMedCrossRefGoogle Scholar
  16. 16.
    Honer WG; Hurwitz T; Li DK; Palmer M; Paty DW. Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders. Arch Neurol. 1987;44: 187–90.PubMedCrossRefGoogle Scholar
  17. 17.
    Huber SJ; Paulson GW; Shuttleworth EC; Chakeres D; Clapp LE; Pakalnis A; Weiss K; Rammohan K. Magnetic resonance imaging correlates of dementia in multiple sclerosis. Arch Neurol. 1987;44: 732–6.PubMedCrossRefGoogle Scholar
  18. 18.
    Izquierdo G; Campoy Jr F; Mir J; Gonzalez M; Martinex-Parra C. Memory and learning disturbances in multiple sclerosis. MRI lesions and neuropsychological correlation. European J Radiology. 1991;13: 220–224.CrossRefGoogle Scholar
  19. 19.
    Pozzilli C; Passafiume D; Bernardi S; Pantano P; Incoccia C; Bastianello S; Bozzao L; Lenzi GL; Fieschi C. Spect, MRI and cognitive functions in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1991;54: 110–115.PubMedCrossRefGoogle Scholar
  20. 20.
    Feinstein A; Kartsounis LD; Miller DH; Youl BD; Ron MA. Clinically isolated lesions of the type seen in multiple sclerosis: a cognitivie, psychiatric, and MRI follow up study. J Neurol Neurosurg Psychiatry. 1992;55: 869–876.PubMedCrossRefGoogle Scholar
  21. 21.
    Mariani C; Farina E; Cappa SF; Anzola GP; Fablia L; Bevilacqua L; Capra R. Neuropsychological assessment in multiple sclerosis: a follow-up study with magnetic resonance imaging. J Neurol 1991;238: 395–400.PubMedCrossRefGoogle Scholar
  22. 22.
    Clark CM; James G; Li D; Oger J; Paty D; Klonoff H. Ventricular size, cognitive function and depression in patients with multiple sclerosis. Can J Neurol Sci. 1992;19: 352–356.PubMedGoogle Scholar
  23. 23.
    Wiebe S; Karlik SJ; Lee DH; Hopkins M; Vandervoort MK; Rice GP; Ebers GC; Noseworthy JH. Serial cranial and spinal cord quantitative MRI in multiple sclerosis: Clinical correlations. Neurology. 1990; 40(Suppl 1): 377.Google Scholar
  24. 24.
    Kastrukoff LF; Oger JJ; Hashimoto SA; Sacks SL; Li DK; Palmer MR; Koopmans RA; Petkau AJ; Berkowitz J; Paty DW. Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. I. Clinical and MRI evaluation. Neurology. 1990;40: 479–86.PubMedCrossRefGoogle Scholar
  25. 25.
    Paty DW; Bergstrom M; Palmer M; MacFadyen J; Li D. A quantitative magnetic resonance image of the multiple sclerosis brain. Am Acad Neurol. Dallas, April 1985, 137.Google Scholar
  26. 26.
    Isaac C; Li DK; Gento M; Jardine C; Grochowski E; Palmer M; Kastrukoff LF; Oger J; Paty DW. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology. 1988;38: 1511–5.PubMedCrossRefGoogle Scholar
  27. 27.
    Thompson AJ; Kermode AG; Wicks D; MacManus DG; Kendall BE; Kingsley DP; McDonald WI. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol. 1991;29: 53–62.PubMedCrossRefGoogle Scholar
  28. 28.
    Bastianello S; Pozzilli C; Bernardi S; Bozzao L; Fantozzi LM Buttinelli C; Fieschi C. Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis. Neurology. 1990;40: 591–5.PubMedCrossRefGoogle Scholar
  29. 29.
    Kappos L; Stadt D; Ratzka M; Keil W; Schneiderbanger Grygier S; Heitzer T; Poser S; Nadjmi M. Magnetic resonance imaging in the evaluation of treatment in multiple sclerosis. Neuroradiology. 1988; 30(4): 299–302.PubMedCrossRefGoogle Scholar
  30. 30.
    Koopmans RA; Li DKB; Zhao GJ; Redekop WK; Paty DW. MRI assessment of cyclosporine therapy of MS in a multi-center trial. Neurology 42(Suppl 3), April 1992, 210.Google Scholar
  31. 31.
    Miller DH; Barkhof F; Berry I; Kappos L; Scotti G; Thompson AJ. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. J Neurol Neurosurg Psychiatry. 1991;54: 683–8.PubMedCrossRefGoogle Scholar
  32. 32.
    IFNB MS Study Group (Sibley W.). Interferon-beta 1b is effective in relapsing-remitting multiple sclerosis: Clinical results of a multiccnter, randomized, double blind, placebo-controlled trial. Neurology. 1993;43: 655–661.CrossRefGoogle Scholar
  33. 33.
    Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology. 1983. 33;1444–52.PubMedCrossRefGoogle Scholar
  34. 34.
    Paty DW; Li DKB; MS/MRI Study Group;IFNB MS Study Group. Interferon-beta-1b is effective in relapsing-remitting multiple sclerosis: II-MRI analysis results of a multicenter randomized, double-blind placebo control trial. Neurology. 1993;43: 662–667.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Donald W. Paty
    • 1
  1. 1.Division of NeurologyThe University of British ColumbiaCanada

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