Intrathecal Cytokine Synthesis in Inflammatory and Demyelinating Diseases of the Central Nervous System

  • Bruno Tavolato
  • Paolo Gallo
Part of the NATO ASI Series book series (NSSA, volume 258)


The immune response is strictly and continuously regulated by a highly complex network of soluble mediators (i.e., cytokines and growth factors) that usually act as autocrine and/or paracrine regulators of cell growth and function. Under pathological conditions, however, when these mediators are produced in larger amounts in tissues or by circulating cells, they can be detected in biological fluids, and may exert hormone-like effects. Thus, the analysis of body fluids (such as serum, cerebrospinal fluid, urine and synovial fluid) for the presence of cytokines may constitute a strategy to define the role of these factors in inflammatory reactions in vivo.


Multiple Sclerosis Human Immunodeficiency Virus Type Tumor Necrosis Factor Alpha Bacterial Meningitis Viral Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Bruno Tavolato
    • 1
  • Paolo Gallo
    • 1
  1. 1.Institute of Neurology, Second Neurologic ClinicUniversity of Padua, School of MedicinePaduaItaly

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