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The Proteolipid Protein Gene Family: Three New Members and Evidence for Their Common Origin from a Primitive Membrane Channel

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A Multidisciplinary Approach to Myelin Diseases II

Part of the book series: NATO ASI Series ((NSSA,volume 258))

Abstract

It has been presumed that the primary role for the proteolipid polypeptides (PLPs: PLP and DM-20) and Po in the generation of the compact myelin sheath in the CNS (PLPs), and PNS (Po) is essentially the same: to mediate via homophilic interactions the self-adhesion of the plasma membrane that yields compact myelin. The molecular basis for adhesive functions at the intraperiod line in the respective nervous systems in which these proteins operate must however be completely different; curiously, these most abundant integral membrane proteins in tetrapods share absolutely no biochemical, genetic or structural features in common with each other.

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Bibliography

  1. Kirschner, D., Ganser A., and Caspar, D. (1984) Diffraction studies of molecular organization and membrane interactions in myelin, in Myelin (Morell, P., ed), pp 51–95. Plenum Press, New York.

    Chapter  Google Scholar 

  2. Lai, C. et al. (1987) Neural protein 1B236/myelin associated glycoprotein (MAG) defines a subgroup of the immunoglobulin gene superfamily. Immunol. Rev. 100: 129–151.

    Article  PubMed  CAS  Google Scholar 

  3. Lemke, G., Lamar, E. and Patterson, J. (1988) Isolation and characterization of the gene encoding the major structural protein of peripheral myelin. Neuron 1: 73–83.

    Article  PubMed  CAS  Google Scholar 

  4. D’Urso D., Brophy, P.J., Staugaitis, S.M., Gillespie, C.S., Frey A.B., Stempak, J.G. and Colman, D.R. (1990) Protein zero of peripheral nerve myelin: biosynthesis, membrane insertion, and evidence for homotypic interaction. Neuron 4: 449–460.

    Article  PubMed  Google Scholar 

  5. Filbin, M.T., Walsh, F.K., Trapp, B.D., Pizzey, J.A. and Tennekoon, G.I. (1990) Role of myelin PO protein as homophilic adhesion molecule. Nature 344: 871–872.

    Article  PubMed  CAS  Google Scholar 

  6. Hudson, L. (1990) Molecular genetics of X-linked mutants. Ann. New York Acad Sci. 605: 155–165.

    Article  CAS  Google Scholar 

  7. Ikenaka, K., Kagawa, T. and Mikoshiba, K. (1992) Selective expression of DM-20, an alternavely spliced myelin proteolipid protein gene product, in developing nervous system and in nonglial cells. J. Neurochem. 58: 2248–2253.

    Article  PubMed  CAS  Google Scholar 

  8. Timsit, S. G., Bally-Cuif, L., Colman, D.R. and Zalc, B. (1992) DM-20 mRNA is expressed during the embyonic development of the nervous system of the mouse. J. Neurochem. 58: 1172–1175.

    Article  PubMed  CAS  Google Scholar 

  9. LeVine, S.M., Wong, D. and Macklin, W.B. (1990) Developmental expression of proteolipid protein and DM20 mRNA and proteins in the rat brain. Dev. Neurosci. 12: 235–250.

    Article  PubMed  CAS  Google Scholar 

  10. Waehneldt, T. (1990) Phylogeny of myelin proteins. Ann. New York Acad. Sci. (605) 15–28.

    Article  CAS  Google Scholar 

  11. Gorr, T., and Kleinschmidt, T. (1993) Evolutionary relationships of the coelacanth. American Scientist 81: 72–82.

    Google Scholar 

  12. Hille, B. (1992) Ionic channels of excitable membranes. (Sinauer Asoociates, Inc., pub., Sunderland, Massachusetts).

    Google Scholar 

  13. Nave, K.A., Lai, C., Bloom, F.E. and Milner R.J. (1987) Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM20 protein of central nervous system myelin. Proc. Natl. Acad. Sci. USA 84: 5665–5669.

    Article  PubMed  CAS  Google Scholar 

  14. Diehl, H.J., Schaich, M., Budzinski, R.M. and Stoffel, W. (1986) Individual exons encode the integral membrane domains of human myelin proteolipid protein. Proc. Natl. Acad. Sci. USA 83, 9807–9811.

    Article  PubMed  CAS  Google Scholar 

  15. Schneider et al. (1992) Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid gene. Nature 238: 758–761.

    Article  Google Scholar 

  16. Pham-Dinh et al. (1991) Pelizaeus-Merzbacher disease: A valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid. Proc. Natl. Acad. Sci. USA 88: 7562–7566.

    Article  PubMed  CAS  Google Scholar 

  17. Waehneldt, T.V., Matthieu, J.M. and Jeserich, G. (1986) Major central nervous system myelin glycoprotein of the african lungfish (Protopterus dolli) cross-reacts with myelin proteolipid protein antibodies, indicating a close phylogenetic relationship with amphibians. J. Neurochem. 46: 1387–1391.

    Article  PubMed  CAS  Google Scholar 

  18. Hudson, L.D., Friedrich, V.L., Behar, T., Dubois-Dalcq, M. and Lazzarini, R.A. (1989) The initial events in myelin synthesis: Orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes. J. Cell Biol. 109: 717–727.

    Article  PubMed  CAS  Google Scholar 

  19. Popot, J. L., Dinh, D.P. and Dautigny, A. (1991) Major myelin proteolipid: the 4-α-helix topology. J. Memb. Biol. 120: 233–246.

    Article  CAS  Google Scholar 

  20. Schliess, F. and Stoffel, W. (1991) Evolution of the myelin integral membrane proteins of the central nervous system. Biol. Chem. Hoppe-Seyler 372, 865–874.

    Article  PubMed  CAS  Google Scholar 

  21. Beyer, E.C., Paul, D.L., and Goodenough, D.A., (1990) Connexin family of gap junction proteins. J. Memb. Biol. 116: 187–194.

    Article  CAS  Google Scholar 

  22. Suter et al. (1992) Trembler mouse carries a point mutation in a myelin gene. Nature 356: 241–244.

    Article  PubMed  CAS  Google Scholar 

  23. Travis, G.H., Sutcliffe, J.G., and Bok, D. (1991) The retinal dgeneration slow (rds) gene product is a photoreceptor disc membrane associated glycoprotein. Neuron 6: 61–70.

    Article  PubMed  CAS  Google Scholar 

  24. Hollmann, M., O’Shea-Greenfield, A., Rogers, S.W. and Heinemann, S. (1989) Cloning by functional expression of a member of the glutamate receptor family. Nature 342, 643–648.

    Article  PubMed  CAS  Google Scholar 

  25. Noda et al. (1983) Primary structure of α-subunit precursor of Torpedo califomica acetylcholine receptor deduced from a cDNA sequence. Nature 301: 251–255.

    Article  PubMed  CAS  Google Scholar 

  26. Colman, D.R., Kreibich, G., Frey, A.B. and Sabatini, D.D. (1982) Synthesis and incorporation of myelin polypeptides into CNS myelin. J. Cell Biol. 95: 598–608.

    Article  PubMed  CAS  Google Scholar 

  27. Lin, L.F.H. and Lees, M.B. (1982) Interaction of dicyclohexylcarbodiimide with myelin proteolipid. Proc. Natl. Acad, Sci. USA 79: 941–945.

    Article  CAS  Google Scholar 

  28. Ting-Beall, H.P., Lees, M.B. and Robertson, J.D. (1979) Interaction of Folch-Lees proteolipid apoprotein with planar lipid bilayers. J. Memb. Biol. 51: 33–46.

    Article  CAS  Google Scholar 

  29. Diaz, R.S., Monreal, J., and Lucas, M. (1990) Calcium movements mediated by proteolipid protein and nucleotides in liposomes prepared with the endogenous lipids from brain white matter. J. Neurochem. 55: 1304–1309.

    Article  PubMed  CAS  Google Scholar 

  30. Helynck, G. et al. (1983) Brain proteolipids. Isolation, purification, and effect on ionic permeability of membranes. J. Biochem. 133: 689–695.

    CAS  Google Scholar 

  31. de Cozar, M., Lucas, M., and Monreal, J. (1987) Ionophoric properties of the proteolipid apoprotein from bovine brain myelin. Biochem. Int. 14: 833–841.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. The Mount Sinai School of Medicine, Brookdale Center for Molecular Biology, One Gustave L. Levy Place, Room 25-22, Box 1126, New York, New York, 10029, USA

    K. Kitagawa & D. R. Colman

Authors
  1. K. Kitagawa
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  2. D. R. Colman
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Editors and Affiliations

  1. Istituto Superiore di Sanità, Rome, Italy

    S. Salvati

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© 1994 Springer Science+Business Media New York

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Kitagawa, K., Colman, D.R. (1994). The Proteolipid Protein Gene Family: Three New Members and Evidence for Their Common Origin from a Primitive Membrane Channel. In: Salvati, S. (eds) A Multidisciplinary Approach to Myelin Diseases II. NATO ASI Series, vol 258. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2435-9_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2435-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6034-6

  • Online ISBN: 978-1-4615-2435-9

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