Abstract
Atopic allergy is a multifactorial disease, and is dependent on several genetic determinants as well as a complex array of environmental factors. A clear causal relationship has been established between the clinical expression of specific allergies and the induction of specific IgE antibody (Ab) responses.1 Several studies have provided evidence for at least two types of genetic control of IgE responses in humans, namely, non-MHC-linked control of the overall production of IgE and MHC-linked control of specific immune responses.2 Since T cells and T-cell cytokines are important in the regulation of IgE synthesis, a detailed investigation of the role of T cells in controlling the synthesis of IgE, and the genetic regulation of various IgE-modulating cytokine genes should provide some useful approaches toward solving the complex problem of the genetic control of IgE production. We have focused on the immunogenetic controls of specific Ab responsiveness to allergens, where the relevant genes clearly include MHC class II (HLA-D), TcR specificity-determining genes. The allergens we studied included a group of “minor” inhalant allergens (relative molecular mass, Mr = ca 4400–5000).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Reference
K. Ishizaka and T. Ishizaka. “Human reaginic antibodies and immunoglobulin E,” J. Allergy 42:330 (1968).
D.G. Marsh, “Historical introduction, In:”Genetic and Environmental Factors in Clinical Allergy,“ D.G. Marsh and M.N. Blumenthal, Eds, University of Minnesota Press, Minneapolis (1990).
D.G. Marsh, “Allergens and the genetics of allergy,” In:“The Antigens,” M. Sela, ed, Academic Press, New York (1975).
D.G. Marsh, “Allergy: A model for studying the genetics of human immune response,” In: “Molecular and Biological Aspects of the Acute Allergic Reaction,” S.G.O. Johansson, K. Strandberg and B. Uvnas, eds, Plenum Publishing Co., New York (1976).
C.B. Lapkoff and L. Goodfriend, “Isolation of a low molecular weight ragweed pollen allergen; Ra5,” Int. Arch. Allergy Appl. Immunol. 46:215 (1974).
L.E. Mole, L. Goodfriend, C.B. Lapkoff, J.M. Kehoe, and J.D. Capra, “The amino acid sequence of allergen Ra5,” Biochem. 14:1216 (1975).
B. Ghosh, M.P. Perry, T. Rafnar, and D.G. Marsh, “Molecular cloning and sequence analysis of the gene encoding the Amb a V allergen from short ragweed (Ambrosia artemisiifolia) pollen,” Submitted.
T. Rafnar, B. Ghosh, S.K. Huang, W.J. Metzler, L. Mueller, and D.G. Marsh, “Expression of cystine-rich ragweed allergens in E. coli: confirmation of the structural and immunological identity of recombinant and native Amb t V for epitope studies,” J. Biol. Chem. (1992). In press.
W.J. Metzler, K. Valentine, M. Roebber, D.G. Marsh, and L. Mueller, “Proton resonance assignments and three-dimensional solution structure of the ragweed allergen Amb a V by nuclear magnetic resonance spectroscopy” Biochemistry. (1992) In press.
L. Goodfriend, A.M. Choudhury, D.G. Klapper, K.M. Coulter, G. Dorval, J. DelCarpio, and C.K. Osterland, “RaSG, a homologue of Ra5 in giant ragweed pollen: isolation, HLA—DR—associated activity and amino acid sequence,” Mol. Immunol. 22:899 (1985).
M. Roebber, D.G. Klapper, L. Goodfriend, W.B. Bias, S.H. Hsu, and D.G. Marsh, “Immunochemical and genetic studies of Amb.t.V (Ra5G), an Ra5 homologue from giant ragweed pollen,” J. Immunol. 134:3062 (1985).
B. Ghosh, M.P. Perry, and D.G. Marsh, “Cloning the cDNA encoding the Amb t V allergen from giant ragweed (Ambrosia trifida) pollen,” Gene 101: 231 (1991).
W.J. Metzler, K. Valentine, M. Roebber, M. Friedrichs, D.G. Marsh, and L. Mueller, “Solution structures of ragweed allergen Amb t V” Biochemistry 31: 5117 (1992).
D.G. Marsh, P. Zwollo, L. Freidhoff, D.B.K. Golden, A.A. Ansari, E.E. Kautzky, D.A. Meyers, and C.L. Holland, “Studies of human immune response to the Amb V (Ra5) homologues,” J. Allergy Clin. Immunol. 85: 201 (1990).
D.G. Marsh, S.H. Hsu, M. Roebber, E.E. Kautzky, L.R. Freidhoff, D.A. Meyers, M.K. Pollard, and W.B. Bias, “HLA—Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure,” J. Exp. Med. 155:1439 (1982).
K.M. Coulter, G.D. Dorval, and L. Goodfriend, “Genetic control of IgE antibody responses in humans: the Amb a V (Ra5) model,” In: D.G. Marsh and M.N. Blumenthal, eds, “Genetic and Environmental Factors in Clinical Allergy,” Univ. of Minnesota Press, Minneapolis (1990).
M.N. Blumenthal, D. Marcus-Bagley, Z. Awdeh, B. Johnson, E.J. Yunis, and C.A. Alper, “HLA-DR2, [HLA-B7, SC31, DR2], and HLA-B8, SCO1, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy,” J. Immunol. 148:411 (1992).
D.G. Marsh, D.A. Meyers, L.R. Freidhoff, E.E. Kautzky, M. Roebber, P.S. Norman, S.H. Hsu, and W.B. Bias, “HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen RaS. II. Response after ragweed immunotherapy,” J. Exp. Med. 155:1452 (1982).
D.G. Marsh, P. Zwollo, S.K. Huang, B. Ghosh, and A.A. Ansari, “Molecular studies of human response to allergens” Cold Spring Harbor Symp. Quant. Biol. 54_ 459 (1990).
P. Zwollo, E.E. Kautzky, A.A. Ansari, S.J. Scharf, H.A. Erlich, and D.G. Marsh, “Molecular studies of human immune response genes for the short ragweed allergen, Amb a V. Sequencing of HLA-D second exons in responders and non-responders,” Immunogenet 46:1050 (1991).
S.K. Huang, P. Zwollo, and D.G. Marsh, “Class II MHC restriction specificity of human T-cell responses to a short ragweed pollen allergen, Amb a V,” Eur. J. Immunol. 21:1469 (1991).
S.K. Huang and D.G. Marsh, “Human T-cell responses to ragweed allergens, Amb V homologues” Immunology 73:363 (1991).
L.R. Freidhoff, E.E. Kautzky, D.A. Meyers, S.H. Hsu, W.B. Bias, and D.G. Marsh, “Association of HLA—DR3/Dw3 and total serum immunoglobulin E level with human immune response to Lol p I and Lol p II allergens in allergic subjects,” Tissue Antigens 31:211 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Huang, SK., Yi, M., Kumai, M., Marsh, D.G. (1994). Immunogenetic Aspects of IgE-Mediated Responses. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VII. Advances in Experimental Medicine and Biology, vol 347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2427-4_2
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2427-4_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6030-8
Online ISBN: 978-1-4615-2427-4
eBook Packages: Springer Book Archive