Skip to main content
SpringerLink
Log in
Book cover

Immunobiology of Proteins and Peptides VII pp 207–220Cite as

Initiation of Autoimmune Type 1 Diabetes and Molecular Cloning of a Gene Encoding for Islet Cell-Specific 37kd Autoantigen

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 347))

Abstract

Diabetes mellitus and its complications are now considered to be the third leading cause of death in North America (Canada and the United States), trailing only cancer and cardiovascular disease. There are two major forms of diabetes mellitus. One is type I diabetes, which is also known as insulin-dependent diabetes mellitus (IDDM), and the other is type II diabetes, which is also known as noninsulin-dependent diabetes mellitus (NIDDM). Most patients with IDDM have a common pathological picture: the nearly total disappearance of insulin-producing pancreatic beta cells, which results in hyperglycemia (Yoon, 1989; Yoon, 1990; Yoon, 1991).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, T.E., Alpert, S., Hanahan, D., 1987, Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325: 223–228.

    Article  PubMed  CAS  Google Scholar 

  • Amano, K., Yoon, J.W., 1990. Studies on autoimmunity for the initiation of beta cell destruction: V. Decrease of macrophage-dependent T-ymphocytes and NK cytotoxicity in silica-treated DP-BB rats. Diabetes 590–596.

    Google Scholar 

  • Bach, J.F., 1988, Mechanisms of autoimmunity in insulin-dependent diabetes mellitus. Clin Exp Immunol 72: 1–8.

    PubMed  CAS  Google Scholar 

  • Baekkeskov, S., Nielsen, J.H., Marner, B., Bilde, T., Ludvigsson, J., Lernmark, A., 1982, Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167–169.

    Article  PubMed  CAS  Google Scholar 

  • Bendelic, A., Carnaud, C., Boiutard, C., Bach, J.F., 1987, Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonate: requirement for both L3T4+ and Lyt2+ T cells. J. Exp. Med. 166: 823–832.

    Article  Google Scholar 

  • Dean, B.M., Walker, R., Bone, A.J., Baird, J.D., Cooke, A., 1985, Pre-diabetes in the spontaneously diabetic BB/E rat: Lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC Class II molecules in endocrine cells. Diabetologia 28: 464–466.

    Article  PubMed  CAS  Google Scholar 

  • Drell, D.W., Notkins, A.L., 1987, Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:132–143.

    Article  PubMed  CAS  Google Scholar 

  • Dyrberg, T., 1986, Humoral autoimmunity in the pathogenesis of insulin-dependent diabetes mellitus. Studies in the spontaneously diabetic BB rat. Acta. Endocrinol. (Suppl.) (Copenh) 280: 1–29.

    CAS  Google Scholar 

  • Gepts, W., 1984, Islet morphology in Type 1 diabetes. Behring Inst Mitt 75: 33–38.

    Google Scholar 

  • Gubler, U. and Hoffman, B.J., 1983, A simple and very efficient method for generating cDNA libraries. Gene 25: 263–269.

    Article  PubMed  CAS  Google Scholar 

  • Haskins, K., Portas, M., Bergman, B., Lafferty, K., Bradley, B., 1989, Pancreatic islet-specific T cell clones from nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 86: 8000–8004.

    Article  PubMed  CAS  Google Scholar 

  • Haskins, K., McDuffie, M., 1990, Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 249: 1433–1436.

    Article  PubMed  CAS  Google Scholar 

  • Ihm, S.H., Lee, K.U., Yoon, J.W., 1991, Studies on autoimmunity for the initiation of beta cell destruction: VII. Evidence for antigenic changes on the beta cells leading to the autoimmune destruction of beta cells in BB rats. Diabetes 40: 269–274.

    Article  PubMed  CAS  Google Scholar 

  • Katoka, S., Satoh, J., Fujiya, H., Toyota, T., Suzuki, R., Itoh, K., Kumagai, K., 1983, Immunological aspects of the nonobese diabetic (NOD) mouse: abnormalities of cellular immunity. Diabetes 32: 247–253.

    Article  Google Scholar 

  • Ko, I.Y., Yoon, J.W., 1991, Delayed expression of islet specific autoantigen in BB rats may be responsible for the initiation of autoimmune type I diabetes. Diabetes 40 (Suppl. 1): 54A.

    Google Scholar 

  • Ko, I.Y., Ihm, S.H. and Yoon, J.W., 1991, Studies on autoimmunity for the initiation of beta cell destruction. VIII. Pancreatic beta cell-dependent autoantibody to a 38 kd protein precedes the clinical onset of diabetes in BB rats. Diabetologia 34: 548–554.

    Article  PubMed  CAS  Google Scholar 

  • Ko, I.Y., 1992, Molecular identification and characterization islet cell-specific 37 kd autoantigen in diabetes-prone BB rats, Ph.D. Thesis, University of Calgary.

    Google Scholar 

  • Koevary, S., Rossini, A.A., Stoller, W., Chick, W., 1983, Passive transfer of diabetes in the BB/W rat. Science 220: 727–728.

    Article  PubMed  CAS  Google Scholar 

  • Koike, T., Itoh, Y., Ishi, T., Ito, I., Takabayashi, K., Maruyama, T., Tomioka, H., Yoshida, S., 1987, Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 36: 539–541.

    Article  PubMed  CAS  Google Scholar 

  • Kolb, H., Kantwert, G., Treichal, U., Kurner, T., Keisel, U., Hoppe, T., Kolb-Bachofen, V., 1986, Natural history of insulitis in BB rats. Pancreas 1: 370.

    Google Scholar 

  • Kolb, H., 1990, Cellular immunity in Type 1 diabetes. IDF Bulletin 35: 37–39.

    Google Scholar 

  • Laupacis, A., Stiller, C.R., Cardell, C., Keown, P., Dupre, J., Wallace, A.C., Thibert, P., 1983, Cyclosporin prevents diabetes in BB Wistar rats. Lancet 1: 10–12.

    Article  PubMed  CAS  Google Scholar 

  • Lee, K.U., Kim, M.K., Amano, K., Pak, C.Y., Jarworski, M.A., Mehta, J.G., Yoon, J.W., 1988a, Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats. Diabetes 37: 1053–1058.

    Article  CAS  Google Scholar 

  • Lee, K.U., Amano, K., Yoon, J.W., 1988b, Evidence for initial involvement of macrophages in development of insulitis in NOD mice. Diabetes 37: 1989–1991.

    Google Scholar 

  • Lee, K.U., Pak, C.Y., Amano, K., Yoon, J.W., 1988c, Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages. Diabetologia 31: 400–402.

    Article  CAS  Google Scholar 

  • Like, A.A., Rossini, A.A., Appel, M.C., Guberski, D.L., Williams, R.M., 1979, Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science 206: 1421–1423.

    Article  PubMed  CAS  Google Scholar 

  • Like, A.A., Kislauskis, E., Williams, R.M., Rossini, A.A., 1982, Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science 216: 644–646.

    Article  PubMed  CAS  Google Scholar 

  • Like, A.A., Anthony, M., Guberski, D.L., Rossini, A.A., 1983, Spontaneous diabetes in the BB/W rat: effects of glucocorticoids, cyclosporin-A and antiserum to rat lymphocytes. Diabetes 32: 326–330.

    Article  PubMed  CAS  Google Scholar 

  • Like, A.A., Biron, C.A., Weringer, E.J., Byman, K., Sroczynski, E., Guberski, D.L., 1986, Prevention of diabetes in Biobreeding/Worcester rats with monoclonal antibodies that recognize T-lymphocytes or natural killer cells. J. Exp. Med. 164: 1145–1159.

    Article  PubMed  CAS  Google Scholar 

  • Marliss, E.B., Nakhooda, A.F., Poussier, P., Simma, A.A.F., 1982, The diabetic syndrome of the “BB” Wistar rat: possible relevance to Type 1 (insulin-dependent) diabetes in man. Diabetologia 22: 225–232.

    Article  PubMed  CAS  Google Scholar 

  • Marliss, E.B., (Ed), 1983, The Juvenile Diabetes Foundation workshop on spontaneously diabetic BB rat as potential for insight into human juvenile diabetes. Metab Clin Exp 32 (Suppl 1) 1–166.

    Google Scholar 

  • Matsudaira, P., 1987, Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262: 10035–38.

    PubMed  CAS  Google Scholar 

  • Miller, B.J., Appel, M.C., O’Neil, J.J., Wicker, L.S., 1988, Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol 140: 52–58.

    PubMed  CAS  Google Scholar 

  • Nagata, M., Yokono, K., Hayakawa, M., Kawase, Y., Hatamori, N., Ogawa, W., Yonezawa, K., Shii, K., Baba, S., 1989, Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice. J. Immunol. 143: 1155–1162.

    PubMed  CAS  Google Scholar 

  • Nagata, M. and Yoon, J.W., 1992, Studies on autoimmunity for T cell-mediated beta cell destruction: Distinct difference in beta cell destruction between CD4+ and CD8+ T cell clones derived from lymphocytes infiltrating the islets of NOD mice. Diabetes 41: 998–1008.

    Article  PubMed  CAS  Google Scholar 

  • Nakano, N., Kikutani, H., Nishimoto, H., Kishimoto, T., 1991, T cell receptor V gene usage of islet ß cell-reactive T cells is not restricted in non-obese diabetic mice. J. Exp. Med. 173: 1091–1097.

    Article  PubMed  CAS  Google Scholar 

  • Oschilewski, U., Kiesel, U., Kolb, H., 1985, Administration of silica prevents diabetes in BB rats. Diabetes 34: 197–199.

    Article  PubMed  CAS  Google Scholar 

  • Reich, E.P., Scaringe, D., Yagi, J., Sherwin, R.S., Janeway Jr. C.A., 1989a, Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes. Diabetes 38: 1647–51.

    Article  CAS  Google Scholar 

  • Reich, E.P., Sherwin, R.S., Kanagawa, O., Janeway, C.A. Jr., 1989b, An explanation for the protective effect of the MHC Class II I-E molecule in murine diabetes. Nature 341: 326–329.

    Article  CAS  Google Scholar 

  • Roep, B.O., Arden, S.D., De Vries, R.R.P., Hutton, J.C., 1990, T-cell clones from a Type 1 diabetes patient respond to insulin secretory granule proteins. Nature 345: 632–634.

    Article  PubMed  CAS  Google Scholar 

  • Rossini, A.A., Mordes, J.P., Like, A.A., 1985, Immunology of insulin-dependent diabetes mellitus. Ann Rev Immunol. 3: 289–320.

    Article  CAS  Google Scholar 

  • Shizuru, J.A., Taylor-Edwards, C., Banks, B.A., Gregory, A.E., Fathman, C.G., 1988, Immunotherapy of the nonobese diabetic mouse: Treatment with an antibody to T-helper lymphocytes. Science 240: 659–662.

    Article  PubMed  CAS  Google Scholar 

  • Short, J.M., Fernandez, J.M., Sorge, J.A. and Huse, M.D., 1988, λ.ZAP: A bacteriophage λ expression vector with in vivo excision properties. Nucleic Acids Res. 16: 7583–7600.

    Article  PubMed  CAS  Google Scholar 

  • Unaue, E.R., 1984, Antigen-presenting function of the macrophage. Ann. Rev. Immunol. 2: 395–428.

    Article  Google Scholar 

  • Unaue, E.R., Allen, P.M., 1987, The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236: 551–557.

    Article  Google Scholar 

  • Voorbij, H.A.M., Jeucken, P.H.M., Kabel, P.J., DeHaan, M., Drexhage, H.A., 1989, Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats. Diabetes 38: 1623–1629.

    Article  PubMed  CAS  Google Scholar 

  • Walker, R., Bone, A.J., Cooke, A., Baird, J.D., 1988, Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats: possible role for macrophages in pathogenesis of IDDM. Diabetes 37: 1301–1304.

    Article  PubMed  CAS  Google Scholar 

  • Wang, Y.I., Hao, L., Gill, R.G., Lafferty, K.J., 1987, Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 36: 535–538.

    Article  PubMed  CAS  Google Scholar 

  • Yoon, J.W., Ihm, S.H., Lee, K.U., Amano, K., Pak, C.Y., 1988a, The initial step in the development of organ specific autoimmune disease in BB rats. Diabetologia 31: 779–780.

    Article  Google Scholar 

  • Yoon, J.W., Leiter, E.H., Coleman, D.L., Kim, M.K., Pak, C.Y., McArthur, R.G. and Roncari, D.A.K., 1988b, Genetic control of organ-reactive autoantibody production in mice by obesity (ob)-Diabetes (db) genes. Diabetes 37: 1287–1293.

    Article  CAS  Google Scholar 

  • Yoon, J.W., 1989, Viral pathogenesis of insulin-dependent diabetes mellitus. Autoimmunity and the Pathogenesis of Diabetes (eds. Ginsberg-Fellner and R.C. McEvoy), Springer-Verlag, New York, pp. 206–257.

    Google Scholar 

  • Yoon, J.W., 1990, Role of viruses and environmental factors in induction of diabetes. In: Human Diabetes: Genetic, Environmental and Autoimmune Etiology. (Eds. Baekkeskov, S. and Hansen, B.) Springer-Verlag, Current Topics in Microbiology and Immunology 164: 95–123.

    Google Scholar 

  • Yoon, J.W., 1991, Role of viruses in the pathogenesis of IDDM. Annals of Medicine 23: 437–445.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Julia McFarlane Diabetes Research Centre and Dept. of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada

    Hee Sook Jun & Ji-Won Yoon

Authors
  1. Hee Sook Jun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji-Won Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Jun, H.S., Yoon, JW. (1994). Initiation of Autoimmune Type 1 Diabetes and Molecular Cloning of a Gene Encoding for Islet Cell-Specific 37kd Autoantigen. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VII. Advances in Experimental Medicine and Biology, vol 347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2427-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2427-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6030-8

  • Online ISBN: 978-1-4615-2427-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation