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Autoantibody Activity and V Gene Usage by B-Cell Malignancies

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Immunobiology of Proteins and Peptides VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 347))

Abstract

During the last few years, we have been particularly interested in the study of the origins and significance of natural autoantibodies. With Guilbert and Avrameasl at Pasteur Institute, we demonstrated the constant presence of natural autoantibodies directed against a broad variety of autoantigens in normal human serum. These results led us to extrapolate them in order to formulate the hypothesis that natural autoantibodies reacting with a wide variety of autoantigens will be found in normal human serum and will constitute a substantial part of normal circulating Igs. Taken together with those reported from other groups, these results challenge the clonal deletion theory as a general and unique explanation for self-tolerance. However, autoantibodies against very specific antigens defining the polymorphism (e.g. the A and B antigens in the case of subjects belonging repectively to the A or B group) or against polymorphic antigens of the major histocompatibility system have not been described. Therefore, clonal deletion mechanisms cannot, at the present time, be completely excluded for such particular cases. In addition, results from transgenic mice led some authors to conclude that clones specific for self antigens associated to cellular membranes are deleted in bone-marrow, whereas clones specific for soluble self antigens are anergized in peripheral lymphoid organs2.

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  1. Immunohematologie et Immunopathologie, Institute Pasteur, 75724, Paris Cedex 15, France

    Guillaume Dighiero

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  1. Guillaume Dighiero
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  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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Dighiero, G. (1994). Autoantibody Activity and V Gene Usage by B-Cell Malignancies. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VII. Advances in Experimental Medicine and Biology, vol 347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2427-4_13

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  • DOI: https://doi.org/10.1007/978-1-4615-2427-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6030-8

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