Physiologic Principles and Clinical Use of Hypothermia

  • Laurie K. Davies
  • Richard F. Davis


Hypothermia has been used to treat a wide variety of diseases for centuries. Lowered body temperature has been used to combat cancer, infections, trauma, central nervous system diseases and as a regional method to produce anesthesia for amputation. {1,2} Although Bigelow demonstrated in 1950 that tolerance to inflow occlusion in hypothermic animals was longer than in their normothermic counterparts, the first clinical application of hypothermia in cardiac surgery was reported by Lewis and Taufic who used surface cooling to 28°C with 5.5 minutes of inflow occlusion to facilitate successful closure of an atrial septal defect in a 5 year old child.{3,4} Despite the introduction of the pump oxygenator in clinical practice by Gibbon in 1954 it was not until 1958 that hypothermia was used in conjunction with the cardiopulmonary bypass circuit for intracardiac repairs.{5,6} The use of the pump oxygenator and hypothermia has allowed the repair of more and more complex cardiac lesions with remarkably low mortality. A better understanding of the underlying physiologic principles of hypothermia will increase its safe clinical application.


Cerebral Blood Flow Cardiopulmonary Bypass Cerebral Perfusion Pressure Circulatory Arrest Deep Hypothermia 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Laurie K. Davies
    • 1
  • Richard F. Davis
    • 1
    • 2
  1. 1.University of Florida College of MedicineGainesvilleUSA
  2. 2.Portland Department of Veterans Affairs Medical CenterOregon Health Sciences UniversityPortlandUSA

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