Abstract
DNA replication is a central feature of the cell cycle, yet very little is known about the control of this process in eukaryotes. Genetic analysis of yeasts has defined proteins with potentially important roles in the control of DNA replication, e.g. CDC28 gene from Saccharomyces cerevisiae and its homolog cdc2 from S. pombe 1–4, for which human functional homologs exist5–8. A homolog of the cdc2 gene product, p34cdc2, has been identified in Xenopus eggs as a component of the mitotic inducer maturation-promoting factor (MPF)9, 10 Active MPF is a complex of p34cdc2 and cyclin B1114. Cyclins are rapidly degraded as cells exit from metaphase15 and therefore must be newly synthesized during interphase of each cell cycle so that cells can generate MPF and progress into mitosis 16, 17. in addition to its role at metaphase, p34cdc2 function is also required at the G1/S transition in yeast.
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Nikaido, T., Ono, K., Yamamoto, M., Sakai, T., Magami, Y. (1994). Cell Cycle Regulation in Normal Versus Leukemic T Cells. In: Hu, V.W. (eds) The Cell Cycle. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2421-2_41
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DOI: https://doi.org/10.1007/978-1-4615-2421-2_41
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