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The Cell Cycle pp 347–357Cite as

Cell Cycle Regulation in Normal Versus Leukemic T Cells

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Abstract

DNA replication is a central feature of the cell cycle, yet very little is known about the control of this process in eukaryotes. Genetic analysis of yeasts has defined proteins with potentially important roles in the control of DNA replication, e.g. CDC28 gene from Saccharomyces cerevisiae and its homolog cdc2 from S. pombe 1–4, for which human functional homologs exist5–8. A homolog of the cdc2 gene product, p34cdc2, has been identified in Xenopus eggs as a component of the mitotic inducer maturation-promoting factor (MPF)9, 10 Active MPF is a complex of p34cdc2 and cyclin B1114. Cyclins are rapidly degraded as cells exit from metaphase15 and therefore must be newly synthesized during interphase of each cell cycle so that cells can generate MPF and progress into mitosis 16, 17. in addition to its role at metaphase, p34cdc2 function is also required at the G1/S transition in yeast.

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA, 19104, USA

    Toshio Nikaido, Koji Ono, Masuji Yamamoto & Yasushi Magami

  2. Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan

    Toshiyuki Sakai

Authors
  1. Toshio Nikaido
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  2. Koji Ono
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  3. Masuji Yamamoto
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  4. Toshiyuki Sakai
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  5. Yasushi Magami
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Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Valerie W. Hu

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© 1994 Springer Science+Business Media New York

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Nikaido, T., Ono, K., Yamamoto, M., Sakai, T., Magami, Y. (1994). Cell Cycle Regulation in Normal Versus Leukemic T Cells. In: Hu, V.W. (eds) The Cell Cycle. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2421-2_41

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  • DOI: https://doi.org/10.1007/978-1-4615-2421-2_41

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-2421-2

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