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Positive and Negative Regulation of Cell Cycle Progression by Serine/Threonine Protein Phosphatases

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Book cover The Cell Cycle

Abstract

Reversible protein phosphorylation events play a key role in intracellular signal transduction pathways that regulate gene expression and cell proliferation. To analyze the involvement of protein phosphatases in these processes, we applied two different approaches. First, we used okadaic acid, a specific inhibitor of the two major serine/threonine protein phosphatases, type 1 (PP-1) and type 2A (PP-2A).1–3 Second, we microinjected subunits of PP-2A into living cells and analyzed the effects on gene expression.

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Authors and Affiliations

  1. Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA, 92093-0636, USA

    Arthur S. Alberts

  2. Department of Microbiology, University of Southern California, 2011 Zonal Ave. HMR-401, Los Angeles, CA, 90033-1054, USA

    Axel Schönthal

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  1. Arthur S. Alberts
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  2. Axel Schönthal
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Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Valerie W. Hu

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Alberts, A.S., Schönthal, A. (1994). Positive and Negative Regulation of Cell Cycle Progression by Serine/Threonine Protein Phosphatases. In: Hu, V.W. (eds) The Cell Cycle. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2421-2_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2421-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6027-8

  • Online ISBN: 978-1-4615-2421-2

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