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The Cell Cycle pp 323–329Cite as

Expression and Regulation of Cyclin Genes in Breast Cancer Cells

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Abstract

The regulatory subunits of cell cycle-regulated kinases, cyclins, are key regulators of cell cycle progression in eukaryotic cells. Mammalian cells contain at least five cyclin classes (cyclins A to E), which reach maximum abundance at different points in the cell cycle1. The transcriptional activation of cyclin genes and consequent transient accumulation of different cyclin proteins which then bind to one of the cyclin-dependent kinases (cdks) to initiate phosphorylation cascades is thought to be the central mechanism for a series of control points in the mammalian cell cycle1–3. in synchronised or growth factor-stimulated mammalian cells, cyclins C, D1, D2, D3 and E are most abundant during G1 phase4–8, suggesting that these cyclins may function at G1 control points. This is supported by recent evidence that cyclin E is rate-limiting for progression through G1 9 and that complex formation between D type cyclins and the cdk4 kinase is maximum in late G1 phase10.

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Authors and Affiliations

  1. Cancer Biology Division, Garvan Institute of Medical Research, St Vincent’s Hospital, Sydney, NSW 2010, Australia

    Elizabeth A. Musgrove, Michael F. Buckley, Anna deFazio, Colin K. W. Watts & Robert L. Sutherland

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  1. Elizabeth A. Musgrove
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  2. Michael F. Buckley
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  3. Anna deFazio
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  4. Colin K. W. Watts
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  5. Robert L. Sutherland
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Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Valerie W. Hu

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© 1994 Springer Science+Business Media New York

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Musgrove, E.A., Buckley, M.F., deFazio, A., Watts, C.K.W., Sutherland, R.L. (1994). Expression and Regulation of Cyclin Genes in Breast Cancer Cells. In: Hu, V.W. (eds) The Cell Cycle. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2421-2_38

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  • DOI: https://doi.org/10.1007/978-1-4615-2421-2_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6027-8

  • Online ISBN: 978-1-4615-2421-2

  • eBook Packages: Springer Book Archive

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