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The Localisation of Human Cyclins and CDKS in the Cell Cycle

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The Cell Cycle
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Abstract

One of the emerging concepts in the cell cycle field is that progress through the cycle is determined at discrete points, called checkpoints, by a family of closely related protein kinases. This family has been christened the ‘cyclin-dependent kinases’ (CDKS), because they are only activated upon binding a member of the cyclin family. Cyclins appear to be required both to activate and to target their protein kinase partner to particular subcellular compartments. I have been attempting to define which part of the cyclin is responsible for its targetting function.

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References

  • Cross, F., 1988, DAF1, a mutant gene affecting size control, pheremone arrest and cell cycle kinetics of S. cerevisiae., Mol. Cell. Biol. 8: 4675.

    PubMed  CAS  Google Scholar 

  • Dasso, M. and Newport, J. W., 1990, Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus, Cell 61: 811.

    Article  PubMed  CAS  Google Scholar 

  • Enoch, T. and Nurse, P., 1990, Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication, Cell 60: 665.

    Article  PubMed  CAS  Google Scholar 

  • Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D. and Hunt, T., 1983, Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division, Cell 33: 389.

    Article  PubMed  CAS  Google Scholar 

  • Featherstone, C. and Russell, P., 1991, Fission yeast p107weel mitotic inhibitor is a tyrosine/serine kinase, Nature 349: 808.

    Article  PubMed  CAS  Google Scholar 

  • Gallant, P. and Nigg, E. A., 1992, Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells, J Cell Biol 117: 213.

    Article  PubMed  CAS  Google Scholar 

  • Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T. and Maller, J. L., 1990, Cyclin is a component of MPF from Xenopus, Cell 60: 487.

    Article  PubMed  CAS  Google Scholar 

  • Girard, F., Strausfeld, U., Fernandez, A. and Lamb, N. J. C., 1991, Cyclin A is required for the onset of DNA replication in mammalian fibroblasts, Cell 67: 1169.

    Article  PubMed  CAS  Google Scholar 

  • Glotzer, M., Murray, A. W. and Kirschner, M. W., 1991, Cyclin is degraded by the ubiquitin pathway, Nature 349: 132.

    Article  PubMed  CAS  Google Scholar 

  • Gould, K. L. and Nurse, P., 1989, Tyrosine phosphorylation of the fission yeast cdc2 + protein kinase regulates entry into mitosis., Nature 342: 39.

    Article  PubMed  CAS  Google Scholar 

  • Krek, W. and Nigg, E. A., 1991, Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites, EMBO Journal 10: 305.

    PubMed  CAS  Google Scholar 

  • Kumagai, A. and Dunphy, W. G., 1991, The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system, Cell 64: 903.

    Article  PubMed  CAS  Google Scholar 

  • Labbé, J. C., Picard, A., Peaucellier, G., Cavadore, J. C., Nurse, P. and Doree, M., 1989, Purification of MPF from starfish: identification as the H1 histone kinase’ p34cdc2 and a possible mechanism for its periodic activation, Cell 57: 253.

    Article  PubMed  Google Scholar 

  • Lehner, C. F. and O’Farrell, P. H., 1989, Expression and function of Drosophila cyclin A during embryonic cell cycle progression, Cell 56: 957.

    Article  PubMed  CAS  Google Scholar 

  • Lew, D. and Reed, S., 1992, A proliferation of cyclins, Trends Cell. Biol. 2: 77.

    Article  PubMed  CAS  Google Scholar 

  • Lundgren, K., Walworth, N., Booher, R., Dembski, M., M., K. and Beach, D., 1991, mikl and weel cooperate in the inhibitory tyrosine phosphorylation of cdc2., Cell 64: 1111.

    Google Scholar 

  • Matsushima, H., Ewen, M. E., Strom, D. K., Kato, J. Y., Hanks, S. K., Roussel, M. F. and Sherr, C. J., 1992, Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins, Cell 71: 323.

    Article  Google Scholar 

  • Meyerson, M., Enders, G. H., Wu, C. L., Su, L. K., Gorka, C., Nelson, C., Harlow, E. and Tsai, L. H., 1992, A family of human cdc2-related protein kinases, Embo J 11: 2909.

    PubMed  CAS  Google Scholar 

  • Millar, J. B. A., McGowan, C. H., Lenaers, G., Jones, R. and Russell, P., 1991, p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast, EMBO J. 10: 4301.

    Google Scholar 

  • Morla, A., Draetta, G., Beach, D. and Wang, J. Y. J., 1989, Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entrance into mitosis., Cell 58: 193.

    Article  PubMed  CAS  Google Scholar 

  • Ookata, K., Hisanaga, S.-i., Okano, T., Tachnibana, K. and Kishimoto, T., 1992, Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes, EMBO J. 5: 1763.

    Google Scholar 

  • Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. and Draetta, G., 1992, Cyclin A is required at two points in the human cell cycle., EMBO J. 11: 961.

    PubMed  CAS  Google Scholar 

  • Pines, J. and Hunter, T., 1991a, Cyclin-dependent kinases: a new cell cycle motifh, Trends Cell Biol. 1: 117.

    Article  PubMed  CAS  Google Scholar 

  • Pines, J. and Hunter, T., 1991b, Human cyclins A and B are differentially located in the cell and undergo cell cycle dependent nuclear transport, J. Cell Biol. 115: 1.

    Article  PubMed  CAS  Google Scholar 

  • Reed, S. I., 1991, G1-specific cyclins: in search of an S-phase promoting factor, Trends. Genet. 7: 95.

    PubMed  CAS  Google Scholar 

  • Russell, P. and Nurse, P., 1987a, The mitotic inducer niml+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis, Cell 49: 569.

    Article  PubMed  CAS  Google Scholar 

  • Russell, P. and Nurse, P., 1987b, Negative regulation of mitosis by wee l+, a gene encoding a protein kinase homolog, Cell 49: 559.

    Article  PubMed  CAS  Google Scholar 

  • Smythe, C. and Newport, J. W., 1992, Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2, Cell 68: 787.

    Article  PubMed  CAS  Google Scholar 

  • Strausfeld, U., Labbé, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P. and Dorée, M., 1991, Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human cdc25 protein, Nature (London) 351: 242.

    Article  CAS  Google Scholar 

  • Xiong, Y., Zhang, H. and Beach, D., 1992, D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA, Cell 71: 504.

    Article  Google Scholar 

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© 1994 Springer Science+Business Media New York

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Pines, J. (1994). The Localisation of Human Cyclins and CDKS in the Cell Cycle. In: Hu, V.W. (eds) The Cell Cycle. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2421-2_22

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  • DOI: https://doi.org/10.1007/978-1-4615-2421-2_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6027-8

  • Online ISBN: 978-1-4615-2421-2

  • eBook Packages: Springer Book Archive

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