Dry Eye Syndromes: Treatment and Clinical Trials

  • Michael A. Lemp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


The evaluation of treatments in medicine has progressed at an accelerated pace in the last half century. No development has been more central to this progress than the advent of the randomized controlled clinical trial. Sir Austin Bradford Hill, who was the father of this scientific genre was judged by the President of the Royal College of Physicians to have made a contribution to medicine “as important and valuable as the discovery of penicillin.”1


Ocular Surface Lacrimal Gland Meibomian Gland Ocular Surface Disease Keratoconjunctivitis Sicca 
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  1. 1.
    H. Atkins, Conduct of a controlled clinical trial, Brit. Med. J. 2:377 (1966).PubMedCrossRefGoogle Scholar
  2. 2.
    F. Ederer, The randomized clinical trial, in: “Clinical Practice and Economic,” C. J. Phillips and J. N. Wolfe, eds., Pitman Press. Bath, Avon (1977).Google Scholar
  3. 3.
    D. Maitland, Clinical trials and health care administrators. Note 42, Notes on Biometry in Medical Research, Washington, D.C., Va Monoge 10–1 (Suppl U) (1969).Google Scholar
  4. 4.
    R. Lewis, Research in medicine: its position and needs, Br. Med. J. 3/15/30: 479.Google Scholar
  5. 5.
    J.W. Bearman, R.B. Loewenson, and W.H. Gullen, Muench’s postulates, laws, and corollaries: a biometricians’ views on clinical studies, in: “Biometrics Note No 4,” Office of Biometry and Epidemiology, NEI, NIH, DHEW. Bethesda, MD.Google Scholar
  6. 6.
    C. Kupfer, Foreword. Evaluating new approaches to the treatment of eye and vision disorders, in: NIH Publication No 90-2910 (1990).Google Scholar
  7. 7.
    F. Ederer, Patient bias, investigator bias and the double-masked procedure in clinical trials, Amer J. Med. 58: 295 (1975)PubMedCrossRefGoogle Scholar
  8. 8.
    D.S. Fredrickson, The field trial; some thoughts on the indispensable ordeal. Bull NY Acad. Med. 44:985 (1968).Google Scholar
  9. 9.
    M.A. Lemp, Basic principles and classification of dry eye disorders, in: “The Dry Eye,” M.A. Lemp and R. Marquardt, eds., Springer-Verlag, New York (1992).Google Scholar
  10. 10.
    J.E. Bearman, Writing the protocol for a clinical trial, Amer. J. Ophthalmol. 79: 775 (1975).Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Michael A. Lemp
    • 1
    • 2
  1. 1.Clinical Professor of OphthalmologyGeorgetown UniversityUSA
  2. 2.University Ophthalmic Consultants of WashingtonUSA

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