A Scanning Electron Micrographic Comparison of the Effects of Two Preservative-Free Artificial Tear Solutions on the Corneal Epithelium as Compared to a Phosphate Buffered Saline and a 0.02% Benzalkonium Chloride Control

  • Kendyl Schaefer
  • Michelle A. George
  • Mark B. Abelson
  • Christopher Garofalo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


Common ophthalmic preservatives can be divided into five classes: quaternary ammonium compounds (benzalkonium chloride), mercurials (thimerisol), alcohols (chlorobutanol), esters of parahydroxybenzoic acid, and other compounds (polymyxin and chlorhexidine).1


Corneal Epithelium Benzalkonium Chloride Dark Cell Rabbit Cornea Keratoconjunctivitis Sicca 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Kendyl Schaefer
    • 1
  • Michelle A. George
    • 1
  • Mark B. Abelson
    • 1
    • 2
  • Christopher Garofalo
    • 1
  1. 1.Department of ImmunologySchepens Eye Research InstituteBostonUSA
  2. 2.Department of OphthalmologyHarvard Medical SchoolBostonUSA

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