Vasoactive Intestinal Peptide Induces Primary Response Gene Expression in Lacrimal Gland

  • Michele M. Cripps
  • Hilary W. Thompson
  • Roger W. Beuerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


The transcription of the proto-oncogene c-fos represents an initial event in the response of diverse tissues to physiologic stimulation. The product of translation of c-fos mRNA is a nuclear phosphoprotein that functions as an activator of transcription by forming a c-fos, c-jun protein heterodimer that possesses DNA binding activity. Activation of the c-fos proto-oncogene and the subsequent cascade of sequential gene expression is initiated by stimulus-transcription coupling events that may involve interactions of ligands with cell-surface receptors and signal transduction by known second messenger pathways (Morgan and Curran, 1991). Many stimuli that are associated with differentiation, proliferation or specific cellular processes that require regulated biosynthesis are capable of eliciting induction of c-fos mRNA and protein.


Vasoactive Intestinal Peptide Lacrimal Gland Corneal Wounding Parotid Acinar Cell Sequential Gene Expression 
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  1. Chirgwin, J.J., Przbyla, A.E., MacDonald, R.J., and Rutter, W.J., 1979, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18:5294.PubMedCrossRefGoogle Scholar
  2. Gripps, M. M., and Patchen-Moor, K., 1989, Inhibition of stimulated lacrimal secretion by [D-ala2] met-enkephalinamide, Am. J. Physiol., 257:G151.Google Scholar
  3. Kaczmarck, L., and Kaminska, B., 1989, Molecular biology of cell activation, Exp. Cell Research 183:24.CrossRefGoogle Scholar
  4. Kousvelari, E. Louis, J. M., Huang, L-H., and Curran, T., 1988, Regulation of proto-oncogenes in rat parotid acinar cells in vitro after stimulation of β-adrenergic receptors, Exp. Cell Research 179:194.CrossRefGoogle Scholar
  5. Lowry, O.H., Rosebrough, N.J., Farr, A. L., and Randall, R.J., 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193:265.PubMedGoogle Scholar
  6. Morgan, J. I., and Curran, T., 1989, Fos and the immediate-early response in the central nervous system. In “Genes and Signal Transduction in Multistage Carcinogenesis”, M.H. Col burn, ed., New York:Dekker.Google Scholar
  7. Morgan, J.I., and Curran, T., 1991, Stimulus-transcription coupling in the nervous system:involvement of the inducible proto-oncogenes fos and jun, Anna. Rev. Neurosci. 14:421.CrossRefGoogle Scholar
  8. Thompson, H.W., Griffith, S., and Beurerman, R.W., 1991, Changes in the expression of the c-fos oncogene and the EGF precursor gene in lacrimal gland following keratectomy wounds of the cornea, Investigative Ophthalmol. Vis. Sci. 32:(Suppl)1112.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Michele M. Cripps
    • 1
  • Hilary W. Thompson
    • 2
  • Roger W. Beuerman
    • 2
  1. 1.Department of PhysiologyLouisiana State University Medical CenterNew OrleansUSA
  2. 2.Department of OphthalmologyLouisiana State University Medical CenterNew OrleansUSA

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