Vasoactive Intestinal Peptide Induces Primary Response Gene Expression in Lacrimal Gland
The transcription of the proto-oncogene c-fos represents an initial event in the response of diverse tissues to physiologic stimulation. The product of translation of c-fos mRNA is a nuclear phosphoprotein that functions as an activator of transcription by forming a c-fos, c-jun protein heterodimer that possesses DNA binding activity. Activation of the c-fos proto-oncogene and the subsequent cascade of sequential gene expression is initiated by stimulus-transcription coupling events that may involve interactions of ligands with cell-surface receptors and signal transduction by known second messenger pathways (Morgan and Curran, 1991). Many stimuli that are associated with differentiation, proliferation or specific cellular processes that require regulated biosynthesis are capable of eliciting induction of c-fos mRNA and protein.
KeywordsVasoactive Intestinal Peptide Lacrimal Gland Corneal Wounding Parotid Acinar Cell Sequential Gene Expression
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