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Vasoactive Intestinal Peptide Induces Primary Response Gene Expression in Lacrimal Gland

  • Michele M. Cripps
  • Hilary W. Thompson
  • Roger W. Beuerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)

Abstract

The transcription of the proto-oncogene c-fos represents an initial event in the response of diverse tissues to physiologic stimulation. The product of translation of c-fos mRNA is a nuclear phosphoprotein that functions as an activator of transcription by forming a c-fos, c-jun protein heterodimer that possesses DNA binding activity. Activation of the c-fos proto-oncogene and the subsequent cascade of sequential gene expression is initiated by stimulus-transcription coupling events that may involve interactions of ligands with cell-surface receptors and signal transduction by known second messenger pathways (Morgan and Curran, 1991). Many stimuli that are associated with differentiation, proliferation or specific cellular processes that require regulated biosynthesis are capable of eliciting induction of c-fos mRNA and protein.

Keywords

Vasoactive Intestinal Peptide Lacrimal Gland Corneal Wounding Parotid Acinar Cell Sequential Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Michele M. Cripps
    • 1
  • Hilary W. Thompson
    • 2
  • Roger W. Beuerman
    • 2
  1. 1.Department of PhysiologyLouisiana State University Medical CenterNew OrleansUSA
  2. 2.Department of OphthalmologyLouisiana State University Medical CenterNew OrleansUSA

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