Abstract
The tear film provides a barrier against pathogenic invasion of the ocular surface. One component of this defense is secretory immunoglobulin A (S-IgA), the predominant immunoglobulin in tears in many species, which is known to be inhibitory for bacterial adhesion.1 IgA is produced by lacrimal gland plasma cells and then transported to the tears by transcytosis following an interaction with secretory component expressed on the surface of epithelial cells. In the mucosal immune network, the precursors of IgA producing plasma cells migrate from sites of antigen encounter to distal mucosal sites such as lacrimal glands. T cells are involved in regulating mucosal immunity and are also retained in the lacrimal gland. The purpose of this study was to further delineate mechanisms responsible for the preferential accumulation of specific lymphoid populations in lacrimal glands.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
J. Meslecky and J.R. McGhee, Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response, Adv. Immunol. 40:153 (1987).
H.B. Stamper and J.J. Woodruff, Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of high-endothelial venules, J. Exp. Med. 144:828 (1976).
H.B. Stamper and J J. Woodruff, An in vitro model of lymphocyte homing. I. characterization of the interaction between thoracic duct lymphocytes and specialized high-endothelial venules of lymph nodes, J. Immunol. 119:1603 (1977).
N.L. O’Sullivan and P.C. Montgomery, Selective interactions of lymphocytes with neonatal and adult lacrimal gland tissues, Invest. Ophthalmol. Vis. Sci. 31:195 (1990).
N.L. O’Sullivan and P.C. Montgomery, Characterization of the lymphocyte-glandular mucosal tissue interaction using an in vitro adherence assay, in: “Advances in Mucosal Immunology,” T.T. MacDonald, J.J. Challacombe, P.W. Bland, C.R. Stokes, R.V. Heally and A.M. Mowat, ed., Kluwer Academic Publishers, Dordrecht, Boston and London, p.222 (1990).
N.L. O’Sullivan and P.C. Montgomery, T and B cell adhesive interactions with lacrimal gland epithelium, Invest. Ophthalmol. Vis. Sci. 32:939 (1991).
N.L. O’Sullivan, C.A. Skandera and P.C. Montgomery, Expression of homing receptor molecules on rat lacrimal gland lymphocytes, in “Recent Advances in Mucosal Immunology,” J. McGhee, J. Mesteeky, H. Tlaskalova and J. Sterzl, eds., Plenum, New York (in press).
L.A. Laskey, M.S. Singer, T.A. Yednock. D. Dowbenko, C. Fennie, H. Rodriguez, T. Nguyen, S. Stachel and S.D. Rosen, Cloning of a lymphocyte homing receptor reveals a lectin domain, Cell 56:1045 (1989).
B.A. Braaten, G.J. Sprangrude and R.A. Daynes, Molecular mechanisms of lymphocyte extravasation. II. studies of in vitro lymphocyte adherence to high endothelial venules, J. Immunol. 113:117 (1984).
S.D. Rosen, M.S. Singer and T.A. Yednock, Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation, Science, 228:1005 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
O’Sullivan, N.L., Raja, R., Montgomery, P.C. (1994). Lymphocyte Adhesive Interaction with Lacrimal Gland Acinar Epithelium Involves Carbohydrate Recognition. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_31
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2417-5_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6025-4
Online ISBN: 978-1-4615-2417-5
eBook Packages: Springer Book Archive