Abstract
One of the more ubiquitous cell types within the parenchyma of the lacrimal gland is the plasma cell. It is solely responsible for the production of immunoglobulins which are secreted into tears. While it is true that immunoglobulins such as IgA are modified by epithelial cells, it is still the plasma cell which acts as the source. In the case of IgG there is no involvement of the epithelium other than to act as a passive filter via the lateral interstitial space1. In terminally differentiated B-lymphocytes or plasma cells the secretion of immunoglobulin has been thought of as a constitutive-like process. The plasma cells simply secrete at a constant rate2. The processes which cause differentiation into plasma cells and hence increased output of immunoglobulin have been major focal points. It is thought that alteration in immunoglobulin output is affected more by changes in cell number rather than dynamic changes within individual cells’ secretory ability.
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Brink, P.R., Walcott, B., Roemer, E., Cameron, R., Pastor, M. (1994). The Role of Membrane Channels in IgG Secretion by Plasma Cells in the Chicken Lacrimal Gland. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_26
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_26
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