Abstract
In the lacrimal gland, cholinergic agonists produce 1,4,5-inositol trisphosphate (1,4,5-IP3) and concomitantly diacyglycerol (DAG) from the hydrolysis of phosphatidylinositol bisphosphate1. 1,4,5-IP3 causes the release of intracellular Ca2+ which causes secretion1. DAG activates protein kinase C (PKC). It has not been determined if cholinergic agonists produce DAG although cholinergic agonists transiently translocate PKC activity and the PKC isozyme PKC-ε from the cytosol2.
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References
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D.A. Dartt, R.R. Hodges, and D.M. Dicker, Protein kinase C, PKC-ε, and Ca2+ in cholinergic activation of lacrimal gland protein secretion, Submitted.
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© 1994 Springer Science+Business Media New York
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Hodges, R.R., Dicker, D.M., Dartt, D.A. (1994). Role of Protein Kinase C in α1-Adrenergic and Cholinergic Agonist Stimulated Protein Secretion. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_25
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_25
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