Abstract
Bromhexine (BH), an oral mucolytic, has shown potential for treating Sjõgren’s Syndrome and particularly Keratoconjunctivitis Sicca (KCS). Studies of both oral formulations (Linstow et al., 1990; Avisar, 1988) and ophthalmic drops (0.2% w/v: Roßman, 1974; Thumm, 1978) have been reported. The low aqueous solubility (≈ 0.2% w/v) of BH precludes adequate ophthalmic bioavailability of BH. In this work, we have designed soluble BH derivatives to rapidly penetrate the accessory glands in the conjunctival stroma in order to improve to topical effectiveness. Histologically, the accessory lacrimal glands are identical to the main lacrimal glands (Gillette et al., 1980) making the former a logical therapeutic target. The in vitro and in vivo protein and tear secretion resulting from stimulation of rabbit lacrimal gland is reported here for our BH derivatives.
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© 1994 Springer Science+Business Media New York
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Schoenwald, R.D., Barfknecht, C.F., Shirolkar, S., Xia, E., Ignace, C.C. (1994). Identification of Sigma Receptors in Lacrimocytes and their Therapeutic Implication in Dry Eye Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_24
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_24
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