Abstract
The purpose of the work presented here is two-fold: 1) to define the role of opioid neuropeptides in the control of lacrimal secretory function and 2) to identify the cellular mechanisms involved in this regulatory process. The opioid peptides met-enkephalin and leu-enkephalin are two of several neuropeptides that have been identified in fibers that terminate near the basal surface of the acini in lacrimal glands of humans (Frey et al., 1986), guinea pigs (Lehtosalo et al., 1989) and rats (Walcott, 1990). In some cases these neuropeptides have been demonstrated in parasympathetic fibers innervating the gland, thus they are colocalized with acetylcholine and VIP. This colocalizalion and the close association of the peptidergic fibers with the secretory structures of the gland suggested that the enkephalins might be important neuromodulators of lacrimal secretion
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Cripps, M.M., Bennett, D.J. (1994). Inhibition of Lacrimal Function by Selective Opiate Agonists. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_22
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_22
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