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A Na:H Exchanger Subtype Mediates Volume Regulation in Bovine Corneal Epithelial Cells

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 350))

Abstract

To identify a role for a Na:H (NHE) exchanger subtype in volume regulation in bovine corneal epithelium, we determined: 1.its sensitivity to inhibition by amiloride analogues 2. the effects of either C1 removal or hypertonicity on the intracellular pH. Our results suggest that volume regulatory responses elicited by stimulation of NHE-2 may help preserve epithelial barrier function in the face of increases in tear film osmolarity.

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References

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Author information

Authors and Affiliations

  1. Physiology and Endocrinology, Medical College of Georgia, Augusta, GA, 30912, USA

    Peter Reinach & Viviana Torres-Zamorano

  2. Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

    Vadivel Ganapathy

Authors
  1. Peter Reinach
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  2. Vadivel Ganapathy
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  3. Viviana Torres-Zamorano
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute and Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan

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© 1994 Springer Science+Business Media New York

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Reinach, P., Ganapathy, V., Torres-Zamorano, V. (1994). A Na:H Exchanger Subtype Mediates Volume Regulation in Bovine Corneal Epithelial Cells. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_18

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  • DOI: https://doi.org/10.1007/978-1-4615-2417-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6025-4

  • Online ISBN: 978-1-4615-2417-5

  • eBook Packages: Springer Book Archive

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