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Immunogold Localization of Prolactin in Acinar Cells of Lacrimal Gland

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes

Abstract

Prolactin (PRL) is known to be involved in osmoregulation and control of cellular differentiation in lower vertebrates (Horobbin, 1980). In mammals, PRL influences sodium and water transport in kidney (Loretz and Bern, 1982) and sweat glands (Robertson et al., 1989), and stimulates the secretion of both fluid and protein in the mammary gland (Olivier-Bousquet, 1978; Houdebine and Dijane, 1989). Although PRL is primarily a product of mammotrophes in the anterior pituitary, it is known to be elaborated by other cell types in the body, including lymphocytes (Buskila, et al., 1991; Lavelle, 1992). PRL receptors also have been found on a number of cells besides mammary secretory cells, again including lymphocytes, and these facts implicate the hormone in immunomodulation, as well as in its better known function in lactogenesis. In fact, Buskila and co-workers (1991) have proposed that PRL may serve as a master hormone controlling immune system function.

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© 1994 Springer Science+Business Media New York

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Wood, R.L., Park, KH., Gierow, J.P., Mircheff, A.K. (1994). Immunogold Localization of Prolactin in Acinar Cells of Lacrimal Gland. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_13

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  • DOI: https://doi.org/10.1007/978-1-4615-2417-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6025-4

  • Online ISBN: 978-1-4615-2417-5

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