Abstract
The secretion of tears by the lacrimal gland is primarily regulated by the autonomic nervous system.1–3 The components of tears are regulated by nerves to reflect different requirements, but the exact nature of neurosecretory interactions in the lacrimal has only been partially elucidated. One reason for this is that the entire pattern of innervation and its relationship to the cells of the lacrimal has not been fully elaborated. In this summary, the innervation of the normal and aged rat lacrimal is described in the context of a brief review of lacrimal innervation. In addition, we describe the presence of mast cells in the gland. A full report of this work has been submitted for publication.4
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References
S.Y. Botelho, M. Hisadad, and N. Fuenmayor, Functional innervation of the lacrimal gland in the cat, Arch. Ophthal. 76:581 (1966).
L.T. Jones. The lacrimal secretory system and its treatment, Am. J. Ophthalmol. 62:47 (1966).
B.B. Bromberg, Autonomic control of protein secretion, Invest. Opthalmol. Vis. Sci. 20:110 (1981).
R.M. Williams, J. Singh, and K. A. Sharkey, The innervation and mast cell content of the rat exorbital lacrimal gland: the effects of age. J. Auton. Nerv. Syst. submitted for publication.
G.L. Ruskell, Changes in nerve terminals and acini of the lacrimal gland and changes in secretion induced by autonomic denervation. Z. Zellforsch. Mikrosk. Anat. 94:261 (1969).
G.L. Ruskell, The distribution of autonomic post-ganglionic nerve fibres to the lacrimal gland in monkeys, J. Anat. 109:229 (1971).
S.Y. Botelho, E.V. Martinez, C. Pholpramool, H.C. van Prooyen, J.T. Janssen, and A. De Palau, Modification of stimulated lacrimal gland flow by sympathetic nerve impulses in rabbit, Am. J. Physiol. 230:80(1976).
D.A. Dartt, A.K. Baker, C. Vaillant, and P.E. Rose, Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini, Am. J. Physiol. 10:G502 (1984).
M. Hussain, and J. Singh, Is VIP the putative non-cholinergic, non-adrenergic neurotransmitter controlling protein secretion in the rat lacrimal glands?, Quart. J. Exp. Physiol. 73:135 (1988).
R.M. Williams, J. Singh, R.W. Lea, E. Adeghate, and K. Sharkey, Evidence for the involvement of vasoactive intestinal polypeptide and neuropeptide Y in the control of enzyme secretion in the isolated rat lacrimal gland, J. Physiol. 459:32P (1993).
J.M Lundberg, Evidence for co-existance of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands, Acta Physiol. Scand. Suppl. 112:1–57 (1981).
A. Nikkinen, J.I. Lehtosalo, H. Uusitalo, A. Palkoma, and P. Panula, The lacrimal glands of the rat and guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal polypeptide, Histochemistry. 81:23 (1984).
Y. Matsumoto, T.Tanabe, S. Ueda, and M. Kawata, Immunohistochemical and enzymehistochemical studies of peptidergic, aminoergic and cholinergic innervation of the lacrimal gland of the monkey (Macaca Fuscata), J. Auton. Nerv. Syst. 37:207 (1991).
P.A. Sibony, B. Walcott, C. McKeon, and F.A. Jakobiec, Vasoactive intestinal polypeptide and the innervation of the human lacrimal gland, Acta. Ophthalmol. 106:1085 (1988).
E. Weihe, D. Norhr, S. Michel, S. Muller, H-J. Zentel, T. Fink, and J. Krekel, Molecular anatomy of the neuro-immune connection, Int. J. Neurosci. 59:1 (1991).
R.S. Kelleher, L.E. Hann, J.A. Edwards, and D.A. Sullivan, Endocrine, neural, and immune control of secretory component output by lacrimal gland acinar cells, J. Immunol. 146:3405 (1991).
D.A. Sullivan, L.E. Hann, C.H. Soo, L. Yee, J.A. Edwards, and M.R. Allansmith, Neural-immune interrelationship: effect of optic, sympathetic, temporofacial, or sensory denervation of the secretory immune system of the lacrimal gland, Reg. Immunol. 3:204 (1991).
C.L. Martin, J. Munnell, R. Kaswan, Normal ultrastrucfure and histochemical characteristics of canine lacrimal glands, Am. J. Vet. Res. 49, 9:1566 (1988).
F. Shanahan, J.A. Denburg, J. Fox, J. Bienenstock, and D. Befus, mast cell heterogenity: effects of neuroenteric peptides on histamine release, J. Immunol. 135:1331 (1985).
P.J. Barnes, Regulatory peptides in the respiratory system, Experientia. 43: 832 (1987).
B.B. Bromberg, and M.H. Welch, Lacrimal protein secretion: Comparison of young and aged lacrimal gland, Exp. Eye Res. 40:313 (1985).
B.B. Bromberg, M.M. Cripps, and M.H. Welch, Sympathomimetic protein secretion by young and aged lacrimal gland, Curr. Eye Res. 5:217 (1986).
K.A. Sharkey, and D. Templeton, Substance P in the rat parotid gland: evidence for a dual origin from the otic and trigeminal ganglia, Brain Res. 304:392 (1984).
R.L. Kaswan, C.L. Martin, and W.L. Chapman, Keratoconjunctivitis sicca: Histopathological study of nicitating membranes and lacrimal glands from 28 dogs, Am. J. Vet. Res. 45:112 (1984).
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Williams, R.M., Singh, J., Sharkey, K.A. (1994). Innervation and Mast Cells of the Rat Lacrimal Gland: the Effects of Age. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_12
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_12
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