Expression of Granzyme A and Perforin in Lacrimal Gland of Sjögren’s Syndrome

  • Kazuo Tsubota
  • Ichiro Saito
  • Nobuyuki Miyasaka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)

Abstract

Tissue destruction of the lacrimal and salivary glands is the cardinal feature of Sjögren’s syndrome. Although lymphocyte infiltration accompanies this destruction, the mechanism of tissue destruction has not been elucidated. Recently, it was suggested that granzyme A and perforin are associated with immune-mediated cytolysis in such autoimmune diseases as rheumatoid arthritis, where the up-regulation of these compounds in synovial fluid lymphocytes causes tissue destruction.1 We have investigated whether granzyme A and perforin are associated with Sjögren’s syndrome.

Keywords

Arthritis Serine Cyclosporin Isothiocyanate Keratoconjunctivitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. Griffiths, S. Alpert, E. Lambert, J. McGuire, and I. Weissman, Perforin and granzyme A expression idendifying cytolytic lymphocytes in rheumatoid arthritis. Proc. Natl. Acad. Sci.USA 89:549 (1992).PubMedCrossRefGoogle Scholar
  2. 2.
    C. Lie, S. Rafii, A. Granelli-Piperno, J. Trapani, and J. Young, Perforin and serine esterase gene expression in stimulated human T cells, J. Exp. Med. 170:2105 (1989).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Kazuo Tsubota
    • 1
    • 2
  • Ichiro Saito
    • 2
  • Nobuyuki Miyasaka
    • 2
  1. 1.Department of OphthalmologyTokyo Dental CollegeChibaJapan
  2. 2.Department of Virology and Immunology, Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan

Personalised recommendations