Abstract
Even though Lyme borreliosis (LB) has been clearly identified as an infectious disease, there are still many riddles to be solved, especially with regard to the immune response to this organism. These include the question why only a small proportion of individuals originally exposed to B. burgdorferi progress to later disease stages, the genetic background and the apparent dissociation between the cellular and humoral immune reactivity with an extensive, but nevertheless restricted and apparently non-protective antibody repertoire.
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References
A. Krause, V. Brade, C. Schoemer, W. Solbach, J.R. Kalden, and G.R. Burmester. 1992. T cell proliferation induced by Borrelia burgdorferi in patients with Lyme borreliosis: Autologous serum required for optimum stimulation. Arthritis Rheum. 34: 393–402
A.G. Barbour, R.A. Heiland, and T.R. Howe. 1985. Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates. J Infect Dis. 152: 478–484
B. Wilske, V. Preac-Mursic, G. Schierz, W. Gueye, P. Herzer, and K. Weber. 1988. Immunochemical analysis of the immune response in late manifestation of Lyme borreliosis. Zentralbl Bakteriol Hyg A. 267: 549–558
L. Zöller, S. Burkhard, and H. Schäfer. 1991. Validity of Western immunoblot band patterns in the serodiagnosis of Lyme borreliosis. J Clin Microbiol. 29: 174–182
A. Krause, G.R. Burmester, A. Rensing, C. Schoemer, U.E. Schaible, M.M. Simon, P. Herzer, M.D. Kramer, and R. Wallich. 1992. Cellular immune reactivity to recombinant OspA and flagellin from Borrelia burgdorferi in patients with Lyme borreliosis. Complexity of humoral and cellular immune responses. J Clin Invest. 90: 1077–1084
H. Yssel, M.-C. Shanafelt, C. Soderberg, P.V. Schneider, J. Anzola, and G. Peltz. 1991. Borrelia burgdorferi activates a T helper type Mike T cell subset in Lyme Arthritis. J Exp Med. 174: 593–601
A.C. Steere, E. Dwyer, and R. Winchester. 1990. Association of chronic Lyme disease with HLA-DR4 and HLA-DR2 alleles. N Engl J Med. 123: 219–223
U.E. Schaible, M.D. Kramer, R. Wallich, T. Tran, and M.M. Simon. 1991. Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur J. Immunol. 21: 2397–2405
M. Rittig, A. Krause, T. Häupl, U.E. Schaible, M. Modolell, M.D. Kramer, E. Lütjen-Drecoll, M.M. Simon, and G.R. Burmester. 1992. Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi. infect Immun. 60: 4205–4212
A.C. Steere, P.H. Duray, and E.C: Butcher. 1988. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue. Arthritis Rheum. 31: 487–495
J. E., Craft, D.K. Fischer, G. T. Shimamoto, and A. C. Steere. 1986. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J. Clin. Invest. 78: 934–939.
B.J. Luft, P.D. Gorevic, W. Jiang, P. Munoz, and R.J. Dattwyler. 1991. Immunologic and structural characterization of the dominant 66- to 73-kDa antigens of Borrelia burgdorferi. J.Immunol. 146: 2776–2782
J.L. Coleman, and J.L. Benach. 1992. Characterization of antigenic determinants of Borrelia burgdorferi shared by other bacteria. J. Infect.Dis. 165: 658–666
V. Preac-Mursic, K. Weber, H.W. Pfister, B. Wilske, B. Gross, A. Baumann, and J. Prokop. 1989. Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 17: 355–359
V. Preac-Mursic, K. Weber, H.W. Pfister, B. Wilske, B. Gross, A. Baumann, and J. Prokop. 1989. Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 17: 355–359
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Burmester, G.R., Häupl, T., Rittig, M. (1994). Cellular Immune Reactions to Borrelia Burgdorferi — the T-Cell-Macrophage Axis. In: Axford, J.S., Rees, D.H.E. (eds) Lyme Borreliosis. NATO ASI Series, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2415-1_26
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DOI: https://doi.org/10.1007/978-1-4615-2415-1_26
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