The Arrangement of tRNA in the Ribosome

  • Alexander S. Spirin
  • Valery I. Lim
  • Richard Brimacombe


The main reaction performed by the translating ribosome is transpeptidation. Two substrates participating in the reaction are peptidyltRNA and aminoacyl-tRNA:

\( {\text{Pept(n) - tRNA' + Aa - tRNA''}} \to {\text{ tRN}}{{\text{A'}}_{{\text{OH}}}}{\text{ + Pept(n + 1) - tRNA''}}{\text{.}} \)

The substrate-binding sites of the ribosome for the two substrates, peptidyl-tRNA and aminoacyl-tRNA, are called the P and A sites, respectively. This is the principal definition of the two sites.


Anticodon Loop Peptidyl Transferase Peptidyl Transferase Center tRNA Anticodon mRNA Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Alexander S. Spirin
    • 1
  • Valery I. Lim
    • 1
  • Richard Brimacombe
    • 2
  1. 1.Institute of Protein ResearchRussian Academy of SciencesMoscow RegionRussia
  2. 2.Abteilung WittmannMax-Planck-Institut für Molekulare GenetikBerlin 33Germany

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