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Ischemic Effects on the Structure and Function of the Plasma Membrane

  • Chapter
Membrane Biogenesis

Part of the book series: Subcellular Biochemistry ((SCBI,volume 22))

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Abstract

The main function of the plasma membrane is to provide a barrier between the intracellular milieu and the extracellular environment. Selective ion transport and cellular ion homeostasis depend on plasma membrane ion channels, transporters, and pumps. The integrity of the plasma membrane rests on the underlying cyto-skeleton connected via integrins with the extracellular matrix or the basement membrane. Ischemia-induced irreversible injury is associated with plasma membrane defects, resulting in the release of intracellular components and disruption of ion, and especially of calcium, homeostasis.

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Authors and Affiliations

  1. Laboratoire de Chimie Physiologique, Facultés Universitaires Notre-Dame de la Paix, Namur, B-5000, Belgium

    Simone Wattiaux-De Coninck & Robert Wattiaux

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  1. Simone Wattiaux-De Coninck
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  2. Robert Wattiaux
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  1. University of Edinburgh, Edinburgh, Scotland, UK

    A. H. Maddy

  2. Institute of Zoology, University of Mainz, Mainz, Germany

    J. R. Harris

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Wattiaux-De Coninck, S., Wattiaux, R. (1994). Ischemic Effects on the Structure and Function of the Plasma Membrane. In: Maddy, A.H., Harris, J.R. (eds) Membrane Biogenesis. Subcellular Biochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2401-4_11

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  • DOI: https://doi.org/10.1007/978-1-4615-2401-4_11

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