Abstract
Consideration of the coalescent process is shown to be useful for analyzing neutral variation linked to loci at which deleterious variation is maintained by mutation-selection balance. Formulas for expected nucleotide diversity and the expected number of polymorphic sites in a sample are obtained. Simulations based on the coalescent process demonstrate that such background selection will rarely result in rejection of the neutral model using Tajima’s D statistic. Models with recombination are also considered.
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© 1994 Springer Science+Business Media Dordrecht
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Hudson, R.R., Kaplan, N.L. (1994). Gene Trees with Background Selection. In: Golding, B. (eds) Non-Neutral Evolution. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2383-3_12
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DOI: https://doi.org/10.1007/978-1-4615-2383-3_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-412-05391-7
Online ISBN: 978-1-4615-2383-3
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