Advertisement

Spoilage mechanisms

  • H. Lockhart
  • F. A. Paine

Abstract

Whether they originate from chemical or biological sources, drugs and medicinal preparations can deteriorate and thus their therapeutic value can be reduced or destroyed. Chemical incompatibility between the ingredients of the medicine or with its packaging materials, as well as the effects of moisture, oxygen, light and temperature changes are the principal causes of such deterioration. Some of these effects may be prevented by suitable formulation of the medicament or its processing and are the province of the pharmaceutical chemist, as part of the product development process. In this chapter, however, the adverse effects that can be reduced or prevented by suitable packaging [1, 2, 3] are examined.

Keywords

Packaging Material Product Development Process Cellulose Film Healthcare Product Climatic Hazard 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Paine FA. Packaging design & performance 1990. Pira International, Surrey, KT22 7RU, UK.Google Scholar
  2. 2.
    Cairns JA, Oswin CR, Paine FA. Packaging for climatic protection. London: Newnes-Butterworths, 1974.Google Scholar
  3. 3.
    Ross CF. Packaging of pharmaceuticals. London: Newnes-Butterworths, 1975.Google Scholar
  4. 4.
    Ostrem FE, Godshall WD. An assessment of the common carrier shipping environment. General Report FPL 22, Forest Products Laboratory, USDA, Madison, WI, 1979.Google Scholar
  5. 5.
    Ostrem FE, Lebovicz B. A survey of environmental conditions incident to the transportation of materials. Report PB-204442, General American Transportation Corp., Niles, IL. 1971.Google Scholar
  6. 6.
    Phillips JP. Package design considerations for the distribution environment. Proceedings of the 1979 International Packaging Week Assembly, Packaging Institute, Stamford, CT, October 1979.Google Scholar
  7. 7.
    ISO 9001 and 9002; British Standards Institution, Milton Keynes and Chiswick.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • H. Lockhart
    • 1
    • 2
    • 3
  • F. A. Paine
    • 4
    • 5
  1. 1.School of PackagingMichigan State UniversityUSA
  2. 2.Center for Food Pharmaceutical ResearchUSA
  3. 3.Committee of RevisionU.S. Pharmacopeial ConventionUSA
  4. 4.School of PackagingMichigan State UniversityUSA
  5. 5.Packaging Technology & ManagementUSA

Personalised recommendations