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Mechanisms of invasion by head and neck cancers

  • Chapter
Head and Neck Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 74))

Abstract

Local and regional spread of squamous cell carcinoma (SCC) of the upper aerodigestive tract represents a major challenge to the oncologist, since it carries a high risk of regional recurrence and a high mortality rate. The invasiveness of these tumors frequently requires surgical resections that impair important physiological functions, including speech and swallowing. The therapy of SCC may be approaching a plateau, as the efficacy and toxicity of the agents used for treatment, particularly chemotherapy, seems to be optimal given present knowledge; therefore, understanding the mechanisms that underlie the invasiveness of SCC is required to develop novel treatments that attenuate the local spread of these tumors. Such anti-invasive agents would not be used alone, but rather in conjunction with existing therapies to improve the overall therapy of head and neck SCC.

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Authors
  1. Douglas D. Boyd
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  2. Garth L. Nicolson
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Editors and Affiliations

  1. M. D. Anderson Cancer Center, The University of Texas, Houston, Texas, USA

    Waun Ki Hong M.D.  & Randal S. Weber M.D.  & 

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Boyd, D.D., Nicolson, G.L. (1995). Mechanisms of invasion by head and neck cancers. In: Hong, W.K., Weber, R.S. (eds) Head and Neck Cancer. Cancer Treatment and Research, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2023-8_6

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  • DOI: https://doi.org/10.1007/978-1-4615-2023-8_6

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