Skip to main content
SpringerLink
Log in

Timing and sequencing of chemoradiotherapy

  • Chapter
Head and Neck Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 74))

Abstract

There are three main objectives in the treatment of cancer: (1) curing disease, (2) keeping the morbidity of treatment to a minimum, and (3) preserving function and cosmesis. It may be difficult to achieve all three of these objectives in all cases. However, cure may be the most important single goal. Thus, a more aggressive treatment regimen with an increase in treatment morbidity or loss of function/cosmesis may be tolerated in order to increase cure rates. Current treatments for cancers of the head and neck can be used to illustrate these principles. Standard treatments for carcinomas of the head and neck include surgery and radiation therapy. Both methods of treatment have been shown to have high cure rates with minimum morbidity when the disease is detected early. For example, radiation therapy alone is curative in the majority of patients with stage I and II glottic carcinoma with preservation of voice. Those few patients who fail radiotherapy are usually salvaged by surgery [1]. Also, newer surgical techniques, such as hemilaryngectomy or laser surgery, have been shown to be curative with voice preservation in selected early glottic cancers, although voice quality is diminished [1]. Cure rates and functional results are also generally good with single modality therapy in early stage tumors located in other head and neck sites. In these favorable cases standard therapy is appropriate, and combined modality therapy should not be considered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Haraf DJ, Weichselbaum RR. Treatment selection in T1 and T2 vocal cord carcinoma. Oncology 2:41–47, 1988.

    PubMed  CAS  Google Scholar 

  2. Cachin Y, Eschwege F. Combination of radiotherapy and surgery in the treatment of head and neck cancers. Cancer Treat Rev 2:177–191, 1975.

    Article  PubMed  CAS  Google Scholar 

  3. Probert JC, Thompson RW, Bagshaw MA. Pattern of spread of distant metastases in head and neck cancer. Cancer 33:127–133, 1974.

    Article  PubMed  CAS  Google Scholar 

  4. Zbaeren P, Lehmann W. Frequency and sites of distant metastases in head and neck squamous cell carcinoma. Arch Otolarygol Head and Neck Surg 113:762–764, 1987.

    Article  Google Scholar 

  5. Takagi M, Kayano T, Yamamoto H, Shibuya H, Hoshina M, Shioda S, Enomoto S. Causes of oral tongue cancer treatment failures. Analysis of autopsy cases. Cancer 69:1081–1087, 1992.

    Article  PubMed  CAS  Google Scholar 

  6. Leibel SA, Scott CB, Mohiuddin M, Marcial VA, Cora LR, Davis LW, Fuks Z. The effect of local-regional control on distant metastatic dissemination in carcinoma of the head and neck: Results of an analysis from the RTOG head and neck database. Int J Radiat Oncol Biol Phys 21:549–556, 1991.

    Article  PubMed  CAS  Google Scholar 

  7. Pinto HA, Jacobs C. Chemotherapy for recurrent and metastatic head and neck cancer. Hematol Oncol Clin North Am 5:667–686, 1991.

    PubMed  CAS  Google Scholar 

  8. Clark JR, Fallon BG, Dreyfuss AI, Norris CM Jr, Anderson JW, Ervin TJ, Anderson RF, Chaffey JT, Mille D, Frei E III. Chemotherapeutic strategies in the multidisciplinary treatment of head and neck cancer. Semin Oncol 15(Suppl 3):35–44, 1988.

    PubMed  CAS  Google Scholar 

  9. Morton RP, Rugman F, Dorman EB, Stoney PJ, Wilson JA, McCormick M, Veevers A, Stell PM. Cisplatinum and bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: A randomized factorial phase III controlled trial. Cancer Chemother Pharmacol 15:283–289, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. DeConti RC, Schoenfeld D. A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin, and a methotrexate combination in head and neck cancer. Cancer 48:1061–1072, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Kaplan BH, Schoenfeld D, Vogl SE. Treatment of recurrent (REC) or metastatic (MET) squamous cancer of the head and neck (SCH&N) with methotrexate (M), M plus Corynebacterium parvum (CP) or M plus bleomycin (B) plus diamminedichloroplatinum (D): A prospective randomized trial of the Eastern Cooperative Oncology Group. Proc Am Assoc Cancer Res 22:532, 1981.

    Google Scholar 

  12. Jacobs C, Meyers F, Hendrickson C, Kohler M, Carter S. A randomized phase III study of cisplatin with or without methotrexate for recurrent squamous cell carcinoma of the head and neck. A Northern California Oncology Group Study. Cancer 52:1563–1569, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Drelichman A, Cummings G, Al-Sarraf M. A randomized trial of the combination of cisplatinum, Oncovin, and bleomycin (COB) versus methotrexate in patients with advanced squamous cell carcinoma of the head and neck. Cancer 52:399–403, 1983.

    Article  PubMed  CAS  Google Scholar 

  14. Vogl SE, Schoenfeld DA, Kaplan BH, Lerner HJ, Engstrom PF, Horton J. A randomized prospective comparison of methotrexate with a combination of methotrexate, bleomycin, and cisplatin in head and neck cancer. Cancer 56:432–442, 1985.

    Article  PubMed  CAS  Google Scholar 

  15. Williams SD, Velez-Garcia E, Essessee I, Ratkin G, Birch R, Einhorn LH. Chemotherapy for head and neck cancer: A combination of cisplatin + vinblastine + bleomycin versus methotrexate. Cancer 57:18–23, 1986.

    Google Scholar 

  16. Jacobs C, Lyman G, Velez-Garcia E, Sridhar KS, Knight W, Hochster H, Goodnough LT, Mortimer JE, Einhorn LH, Schacter L, et al. A phase III study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 10:257–263, 1992.

    PubMed  CAS  Google Scholar 

  17. Forastiere A, Metchy B, Keppen M, Schuller D, Ensley J, Coltmann C Jr. Randomized comparison of cisplatin + 5-fluorouracil (5-FU) vs. carboplatin + 5-FU vs. methotrexate in advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 8:168, 1989.

    Google Scholar 

  18. The Liverpool Head and Neck Oncology Group. A phase III randomized trial of cis-platinum, methotrexate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Br J Cancer 61:311–315, 1990.

    Article  Google Scholar 

  19. Steele GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity. Int J Radiat Oncol Biol Phys 5:85–91, 1979.

    Article  Google Scholar 

  20. Vokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: Rationale and clinical experience in patients with solid tumors. J Clin Oncol 8:911–934, 1990.

    PubMed  CAS  Google Scholar 

  21. Bentzen SM, Johansen LV, Overgaard J, Thames HD. Clinical radiobiology of squamous cell carcinoma of the oropharynx. Int J Radiat Oncol Biol Phys 20:1197–1206, 1991.

    Article  PubMed  CAS  Google Scholar 

  22. Taylor JMG, Whithers HR, Mendenhall WM. Dose-time considerations of head and neck squamous cell carcinomas treated with irradiation. Radiother Oncol 17:95–102, 1990.

    Article  PubMed  CAS  Google Scholar 

  23. Ensley J, Jacobs J, Weaver A, Kinzie J, Crissman J, Kish J, Cummings G, Al-Sarraf M. Correlation between response to cisplatinum-combination chemotherapy and subsequent radiotherapy in previously untreated patients with advanced squamous cancers of the head and neck. Cancer 54:811–814, 1984.

    Article  PubMed  CAS  Google Scholar 

  24. Clark JR, Fallon BG, Dreyfuss AI, Norris CM Jr, Anderson JW, Ervin TJ, Anderson RF, Chaffey JT, Miller D, Frei E 3d. Chemotherapeutic strategies in the multidisciplinary treatment of head and neck cancer. Semin Oncol 15(Suppl 3):35–44, 1988.

    Google Scholar 

  25. Vokes EE, Moran WJ, Mick R, Weichselbaum RR, Panje WR. Neoadjuvant and adjuvant methotrexate, cisplatin and flourouracil in multimodal therapy of head and neck cancer. J Clin Oncol 7:838–845, 1989.

    PubMed  CAS  Google Scholar 

  26. Vokes EE, Panje WR, Mick R, Kozloff MF, Moran WJ, Sutton HS, Goldman MD, Tybor AG, Weichselbaum RR. A randomized study comparing two regimens of neoadjuvant chemotherapy in multimodal therapy for locally advanced head and neck cancer. Cancer 66:206–213, 1990.

    Article  PubMed  CAS  Google Scholar 

  27. Dreyfus AI, Clark JR, Wright JE, Norris CM Jr, Busse PM, Lucarini JW, Fallon BG, Casey D, Andersen JW, Klein R, et al. Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Intern Med 112:167–172, 1990.

    Google Scholar 

  28. Rooney M, Kish J, Jacobs J, Kinzie J, Weaver A, Crissman J, Al-Sarraf M. Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin. Cancer 55:1123–1128, 1985.

    Article  PubMed  CAS  Google Scholar 

  29. Ensley J, Kish J, Tapazoglou E, Jacobs J, Weaver A, Atkinson D, Ahmed K, Mathog R, Al-Sarraf M. An intensive, five course, alternating combination chemotherapy induction regimen used in patients with advanced, unresectable head and neck cancer. J Clin Oncol 6:1147–1153, 1988.

    PubMed  CAS  Google Scholar 

  30. Kies MS, Gordon LI, Hauck WW, Krespi Y, Ossoff RH, Pecaro BC, Yuska C, Lamut CH, Brand WN, Chang SK, et al. Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer. Otolaryngol Head Neck Surg 93:199–205, 1985.

    PubMed  CAS  Google Scholar 

  31. Vokes EE, Mick R, Lester EP, Panje WR, Weichselbaum RR. Cisplatin and flourouracil chemotherapy does not yield long-term benefit in locally advanced head and neck cancer: Results from a single institution. J Clin Oncol 9:1376–1384, 1991.

    PubMed  CAS  Google Scholar 

  32. Dreyfuss AI, Clark JR. Analysis of prognostic factors in squamous cell carcinomas of the head and neck. Hematol Oncol Clin North Am 5:701–712, 1991.

    PubMed  CAS  Google Scholar 

  33. Hill BT, Price LA, MacRae K. Importance of site in addressing chemotherapy response and 7 year survival data in advanced squamous-cell carcinomas of the head and neck treated with initial combination chemotherapy without cisplatin. J Clin Oncol 4:1340–1347, 1986.

    PubMed  CAS  Google Scholar 

  34. Mick R, Vokes EE, Weichselbaum RR, Panje WR. Prognostic factors in advanced head and neck cancer patients undergoing multimodal therapy. Otolaryngol Head Neck Surg 105:62–73, 1991.

    PubMed  CAS  Google Scholar 

  35. Knowlton AH, Percarpio B, Bobrow S, Fischer JJ. Methotrexate and radiation in the treatment of advanced head and neck tumors. Radiology 116:709–712, 1975.

    PubMed  CAS  Google Scholar 

  36. Fazekas JT, Sommer C, Kramer S. Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx. Int J Radiat Oncol Biol Phys 6:533–541, 1980.

    Article  PubMed  CAS  Google Scholar 

  37. Taylor SG, Applebaum E, Showel JL, Norusis M, Holinger LD, Hutchinson JC Jr, Murthy AK, Caldarelli DD. A randomized trial of adjuvant chemotherapy in head and neck cancer. J Clin Oncol 3:672–679, 1985.

    PubMed  Google Scholar 

  38. Stell PM, Dalby JE, Strickland P, Fraser JG, Bradley PJ, Flood LM. Sequential chemotherapy and radiotherapy in advanced head and neck cancer. Clin Radiol 34:463–467, 1983.

    Article  PubMed  CAS  Google Scholar 

  39. Holoye PY, Grossman TW, Toohill RJ, Kun LE, Byhardt RW, Duncavage JA, Byhardt RW, Ritch PS, Grossman TW, Hoffmann RG, Cox JD, Malin T. Randomized study of adjuvant chemotherapy for head and neck cancer. Otolaryngol Head Neck Surg 93: 712–717, 1985.

    PubMed  CAS  Google Scholar 

  40. Martin M, Hazan A, Vegnes L, Peytral C, Mazeron JJ, Senechaut JP, Lelievre G, Peynegre R. Randomized study of 5-fluorouracil and cisplatin as neoadjuvant therapy in head and neck cancer: A preliminary report. Int J Radiat Oncol Biol Phys 19:973–975, 1990.

    Article  PubMed  CAS  Google Scholar 

  41. Toohill RJ, Anderson T, Byhardt RW, Cox JD, Duncavage JA, Grossman TW, Haas CD, Haas JS, Hartz AJ, Libnoch JA, et al. Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. Arch Otolaryngol Head Neck Surg 113:758–761, 1987.

    Article  PubMed  CAS  Google Scholar 

  42. Schuller DE, Metch B, Mattox D, Stein DW, McCracken JD. Preoperative chemotherapy in advanced resectable head and neck cancer: Final report of the Southwest Oncology Group. Laryngoscope 98:1205–1211, 1988.

    Article  PubMed  CAS  Google Scholar 

  43. Final Report of the Head and Neck Contracts Program. Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Cancer 60:301–311, 1987.

    Article  Google Scholar 

  44. Jacobs C, Mauch R. Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: A subset analysis of the head and neck contracts program. J Clin Oncol 8:838–847, 1990.

    PubMed  CAS  Google Scholar 

  45. The Department of Veteran Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685–1690, 1991.

    Article  Google Scholar 

  46. Laramore GE, Wolf GT, Fisher SG, et al. Surgery and postoperative radiotherapy vs. induction chemotherapy and definitive radiotherapy for advanced laryngeal cancer: Control of neck disease and distant metastases as a function of nodal staging (abstr). Proc Am Radium Soc 74:14, 1992.

    Google Scholar 

  47. Jacobs C, Goffinet DR, Goffinet L, Kohler M, Fee WE. Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer. A report from the Northern California Oncology Group. Cancer 60:1178–1183, 1987.

    Article  PubMed  CAS  Google Scholar 

  48. Pfister DG, Strong E, Harrison L, Haines IE, Pfister DA, Sessions R, Spiro R, Shah J, Gerold F, McLure T, et al. Larynx preservation with combined chemotherapy and radiation therapy in advanced but resectable head and neck cancer. J Clin Oncol 9:850–859, 1991.

    PubMed  CAS  Google Scholar 

  49. Karp DD, Vaughan CW, Carter R, Willett B, Heeren T, Calarese P, Zeiteis S, Strong MS, Hong WK. Larynx preservation using induction chemotherapy plus radiation therapy as an alternative to laryngectomy in advanced head and neck cancer. A long-term follow-up report. Am J Clin Oncol 14:273–279, 1991.

    Article  PubMed  CAS  Google Scholar 

  50. Laramore GE, Scott CB, Al-Sarraf M, Haselow RE, Ervin TJ, Wheeler R, Jacobs R. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report on intergroup study 0034 (abstr). Int J Radiat Oncol Biol Phys 21(Suppl 1):190, 1991.

    Article  Google Scholar 

  51. Vokes EE, Weichselbaum RR, Mick R, McEvilly JM, Haraf DJ, Panje WR. Favorable long-term survival following induction chemotherapy with cisplatin, flourouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. J Natl Cancer Inst 84:877–882, 1992.

    Article  PubMed  CAS  Google Scholar 

  52. Ansfield FJ, Ramirez G, Davis HL, Korbitz BC, Vermund H, Gollin FF. Treatment of advanced cancer of the head and neck. Cancer 25:78–82, 1970.

    Article  PubMed  CAS  Google Scholar 

  53. Lo TC, Wiley AL Jr, Ansfield FJ, Brandenburg JH, Davis HL Jr, Gollin FF, Johnson RO, Ramirez G, Vermund H. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: A randomized study. Am J Roentgenol 126:229–235, 1976.

    CAS  Google Scholar 

  54. Shanta V, Krishnamurthi S. Combined bleomycin and radiotherapy in oral cancer. Clin Radiol 31:617–620, 1980.

    Article  PubMed  CAS  Google Scholar 

  55. Vermund H, Kaalhus O, Winther F, Trausjo J, Thorud E, Harang R. Bleomycin and radiation therapy in squamous cell carcinoma of the upper aero-digestive tract: A phase III clinical trial. Int J Radiat Oncol Biol Phys 11:1877–1886, 1985.

    Article  PubMed  CAS  Google Scholar 

  56. Eschwege F, Sancho-Garnier H, Gerard JP, Madelain M, DeSaulty A, Jortay A, Canchin Y. Ten-year results of randomized trial comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx: Experience of the European Organization for Research and Treatment of Cancer. Monogr Natl Cancer Inst 6:275–278, 1988.

    Google Scholar 

  57. Fu KK, Phillips TL, Silverberg KJ, Jacobs C, Goffinet DR, Chun C, Friedman MA, Kohler M, McWhirter K, Carter SK. Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: Update of a Northern California Oncology Group Randomized Trial. J Clin Oncol 5:1410–1418, 1987.

    PubMed  CAS  Google Scholar 

  58. Weissberg JB, Son YH, Papac RJ, Sasaki C, Fischer DB, Lawrence R, Rockwell S, Sartorelli AC, Fischer JJ. Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys 17:3–9, 1989.

    Article  PubMed  CAS  Google Scholar 

  59. Gupta NK, Pointon RCS, Wilkinson PM. A randomized trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer. Clin Radiol 38:575–581, 1987.

    Article  PubMed  CAS  Google Scholar 

  60. Coughlin CT, Richmond RC. Biologic and clinical developments of cisplatin combined with radiation: Concepts, utility, projections for new trials, and emergence of carboplatin. Semin Oncol 16(Suppl 6):31–43, 1989.

    PubMed  CAS  Google Scholar 

  61. Douple EB. Keynote address: Platinum-radiation interactions. Monogr Natl Cancer Inst 6:315–319, 1988.

    Google Scholar 

  62. Al-Sarraf M, Pajak TF, Marcial VA, Mowry P, Cooper JS, Stetz J, Ensley JF, Velez-Garcia E. Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck. Cancer 59:259–265, 1987.

    Article  PubMed  CAS  Google Scholar 

  63. Haselow RE, Warshaw MG, Oken MM, Adams GL, Aughey JL, Cooper JS, Schuller DE, Jacobs CD. Radiation alone versus radiation with weekly low dose cisplatinum in unresectable cancer of the head and neck. In: Fee WE, Goepfert H, Johns ME, Strong E, Ward PH, eds. Head and Neck Cancer. Toronto: B.C. Decker, 1990, pp 279–281.

    Google Scholar 

  64. Eisenberger M, Van Echo D, Aisner J. Carboplatin: The experience in head and neck cancer. Semin Oncol 16:34–41, 1989.

    PubMed  CAS  Google Scholar 

  65. Richards GJ, Chambers RG. Hydroxyurea: A radiosensitizer in the treatment of neoplasms of the head and neck. Am J Roengenol Radium Nucl Med 55:555–565, 1969.

    Google Scholar 

  66. Piver MS, Barlow JJ, Vongtama V, Blumenson L. A radiation potentiator in carcinoma of the uterine cervix. A randomized double-blind study. Am J Obstet Gynecol 147:803–808, 1983.

    PubMed  CAS  Google Scholar 

  67. Taylor SG, Murthy AK, Caldarelli DD, Showel JL, Kiel K, Griem KL, Mittal BB, Kies M, Hutchinson JC Jr, Holinger LD, Campanella R, Witt TR, Hoover S. Combined simultaneous cisplatin/fluorouracil chemotherapy and split course radiation in head and neck cancer. J Clin Oncol 7:846–856, 1989.

    PubMed  Google Scholar 

  68. Vokes EE, Panje WR, Schilsky RL, Mick R, Awan AM, Moran WJ, Goldman MD, Tybor AG, Weichselbaum RR. Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer. J Clin Oncol 7:761–768, 1989.

    PubMed  CAS  Google Scholar 

  69. Haraf DJ, Vokes EE, Panje WR, Weichselbaum RR. Survival and analysis of failure following hydroxyurea, 5-fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. Am J Clin Oncol 14:419–426, 1991.

    Article  PubMed  CAS  Google Scholar 

  70. Haraf DJ, Vokes EE, Weichselbaum RR, Panje WR. Concomitant chemoradiotherapy with cisplatin, 5-fluorouracil and hydroxyurea in poor prognosis head and neck cancer. Laryngoscope 102:630–636, 1992.

    Article  PubMed  CAS  Google Scholar 

  71. Wendt TG, Hartenstein RC, Wustrow TPU, Lissner J. Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: A phase II study. J Clin Oncol 7:471–476, 1989.

    PubMed  CAS  Google Scholar 

  72. Adelstein DJ, Sharan VM, Earle AS, Shah AC, Vlastou C, Haria CD, Carter SG, Damm C, Hines JD: Long-term results after chemoradiotherapy for locally confined squamous-cell head and neck cancer. Am J Clin Oncol 13:440–447, 1990.

    Article  PubMed  CAS  Google Scholar 

  73. Merlano M, Rosso R, Benasso M, Corvo R, Margarino G, Rubagotti A, Zarrilli D, Toma S, Brema F, Grimaldi A, Luzi G, Vitale V. Alternating chemotherapy (CT) and radiotherapy (RT) vs RT in advanced inoperable SCC-HN: A cooperative randomized trial (abstr). Proc Am Soc Clin Oncol 10:198, 1991.

    Google Scholar 

  74. Merlano M, Benasso M, Blengio F. The integration of chemotherapy and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck. J Infusional Chemother 2:16–20, 1992.

    Google Scholar 

  75. South-East Co-operative Oncology Group. A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. An interim report. Eur J Surg Oncol 12:289–295, 1986.

    Google Scholar 

  76. Adelstein DJ, Sharan VM, Earle AS, Shah AC, Vlastou C, Haria CD, Damm C, Carter SG, Hines JD. Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer. Cancer 65:1685–1691, 1990.

    Article  PubMed  CAS  Google Scholar 

  77. Merlano M, Corvo R, Margarino G, Benasso M, Rosso R, Sertoli MR, Cavallari M, Scala M, Guenzi M, Siragusa A, Brema F, Luzi G, Bottero G, Bioni G, Scasso F, Garaventa G, Accomando E, Santelli A, Cordone G, Cornelia G, Vitriolo S, Santi L. Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck. The final report of a randomized trial. Cancer 67:915–921, 1991.

    Article  PubMed  CAS  Google Scholar 

  78. Horiot JC, Le Fur R, N’Guyen T, Chenal C, Schraub S, Alfonsi S, Gardani G, Van den Bogaert W, Danczak S, Bolla M, et al. Hyperfractionated compared with conventional radiotherapy in oropharyngeal carcinoma: An EORTC randomized trial. Eur J Cancer 26:779–780, 1990.

    Article  PubMed  CAS  Google Scholar 

  79. Pinto LHJ, Canary PCV, Araujo CMM, Bacelar SC, Souhami L. Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stages III and IV oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 21:557–562, 1991.

    Article  PubMed  CAS  Google Scholar 

  80. Saunders MI, Dische S, Hong A, Grosch EJ, Fermont DC, Ashford RFU, Maher EJ. Continuous hyperfractionated accelerated radiotherapy in locally advanced carcinoma of the head and neck region. Int J Radiat Oncol Biol Phys 17:1287–1293, 1989.

    Article  PubMed  CAS  Google Scholar 

  81. Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RFU, Maher EJ, Makepeace AR. Experience with CHART. Int J Radiat Oncol Biol Phys 21:871–878, 1991.

    Article  PubMed  CAS  Google Scholar 

  82. Choi KN, Rotman M, Aziz H, et al. Locally advanced paranasal sinus and nasopharynx tumors treated with hyperfractionated radiation and concurrent infusion cisplatin. Cancer 67:2748–2752, 1991.

    Article  PubMed  CAS  Google Scholar 

  83. Sanchiz F, Milla A, Torner J, Bonet F, Artola N, Carreno L, Moya LM, Riera D, Ripol S, Cirera L. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int J Radiat Oncol Biol Phys 19:1347–1350, 1990.

    Article  PubMed  CAS  Google Scholar 

  84. Lindstrom MJ, Fowler JF. Analysis of the time factor in local control by radiotherapy of T3T4 squamous cell carcinoma of the larynx. Int J Radiat Oncol Biol Phys 21:813–817, 1991.

    Article  PubMed  CAS  Google Scholar 

  85. Whithers HR, Taylor JMG, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27:131–146, 1988.

    Article  Google Scholar 

Download references

Authors
  1. Daniel J. Haraf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ralph R. Weichselbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Everett E. Vokes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. M. D. Anderson Cancer Center, The University of Texas, Houston, Texas, USA

    Waun Ki Hong M.D.  & Randal S. Weber M.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Haraf, D.J., Weichselbaum, R.R., Vokes, E.E. (1995). Timing and sequencing of chemoradiotherapy. In: Hong, W.K., Weber, R.S. (eds) Head and Neck Cancer. Cancer Treatment and Research, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2023-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2023-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5837-4

  • Online ISBN: 978-1-4615-2023-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation