The Current Status of Bone Marrow Transplantation and Gene Therapy in the Management of the Haemoglobinopathies

  • J. F. Apperley
  • I. A. G. Roberts
Part of the Developments in Hematology and Immunology book series (DIHI, volume 30)


Since the first successful bone marrow transplants (BMT) were reported [1–3], clinicians have been aware of their potential for the treatment of the haemoglobinopathies. To date the procedural risks of BMT have precluded its widespread use for thalassaemiaand sickle cell disease. However as the risks of BMT have decreased due to a combination of increasing experience and improved techniques, it has become a viable alternative to medical treatment in selected cases. The decision to advocate transplant remains difficult, but the information now available regarding the outcome of BMT has enabled us to identify suitable patient groups.


Sickle Cell Disease Graft Versus Host Disease Globin Gene Chelation Therapy Event Free Survival 
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© Springer Science+Business Media Dordrecht 1995

Authors and Affiliations

  • J. F. Apperley
  • I. A. G. Roberts

There are no affiliations available

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