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Peripheral Blood Stem Cell Transplantation

  • William Bensinger
Part of the Cancer Treatment and Research book series (CTAR, volume 76)

Abstract

High-dose chemoradiotherapy followed by autologous or allogeneic marrow rescue has revolutionized oncology and become the new standard of care for a variety of malignant diseases previously treated with conventional dose chemotherapy. Peripheral blood stem cells (PBSC) promise to provide a similar revolution for the source of hematopoietic stem cells. In this chapter, the term PBSC is used to define a heterogeneous population of committed and uncommitted hematopoietic precursor cells in the peripheral blood that in toto are capable of short- and long-term engraftment. The relative ease of collection and the markedly shorter recovery time for peripheral counts after marrow ablative therapy suggest that PBSC will supplant marrow for both allogeneic and autologous transplantation in the next 5 years.

Keywords

Clin Oncol Chronic Myelogenous Leukemia Acute Myelogenous Leukemia Peripheral Blood Stem Cell Peripheral Blood Stem Cell Transplant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brecher G, Cronkite EP: Post-radiation parabiosis and survival in rats. Proc Soc Exp Biol Med 77:292, 1951.PubMedGoogle Scholar
  2. 2.
    Merwin RM: Repopulation of hematopoietic tissues of X-irradiated mice by cells from leukemoid blood. Proc Soc Exp Biol Med 101:9, 1959.PubMedGoogle Scholar
  3. 3.
    Goodman JW, Hodgson GS: Evidence for stem cells in the peripheral blood of mice. Blood 19:702–714, 1962.PubMedGoogle Scholar
  4. 4.
    Storb R, Epstein RB, Ragde H, Thomas ED: Marrow engraftment by allogeneic leukocytes in lethally irradiated dogs. Blood 30:805–811, 1967.PubMedGoogle Scholar
  5. 5.
    Epstein RB, Graham TC, Buckner CD, Thomas ED: Allogeneic marrow engraftment by cross circulation in lethally irradiated dogs. Blood 28:692–707, 1966.PubMedGoogle Scholar
  6. 6.
    Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED: Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood 50:537–542, 1977.PubMedGoogle Scholar
  7. 7.
    McCredie KB, Hersh EM, Freireich EJ: Cells capable of colony formation in the peripheral blood of man. Science 171:293–294, 1971.PubMedGoogle Scholar
  8. 8.
    Buskard NA, Kaur J, Goldman JM, Spiers ASD, Galton DAG: Engraftment with chronic granulocytic leukemia cells in acute myeloid leukaemia. Transfusion 19:317, 1979.PubMedGoogle Scholar
  9. 9.
    McCredie KB, Freireich EJ, Hersh EM, Curtis JE, Kaiser H: Early bone marrow recovery after chemotherapy following the transfusion of peripheral blood leukocytes in identical twins. Proc Am Assoc Cancer Res 11:54, 1970.Google Scholar
  10. 10.
    Hershko C, Ho WG, Gale RP, Cline MJ: Cure of aplastic anemia in paroxysmal nocturnal haemoglobinuria by marrow transfusion from an identical twin: Failure of peripheral-leukocyte transfusion to correct marrow aplasia. Lancet 2:945, 1979.Google Scholar
  11. 11.
    Abrams RA, Glaubiger D, Appelbaum FR, Deisseroth AB: Results of attempted hematopoietic reconstitution using isologous, peripheral blood mononuclear cells: A case report. Blood 56:516–520, 1980.PubMedGoogle Scholar
  12. 12.
    Goldman JM, Catovsky D, Goolden AWG, Johnson SA, Galton DAG: Buffy coat autografts for patients with chronic granulocytic leukaemia in transformation. Blut 42:149, 1981.PubMedGoogle Scholar
  13. 13.
    Goldman JM, Kearney L, Pittman S, Baughan ASJ, Worsley AM, Catovsky D, Geary C, Samson D, Gordon-Smith EC, Galton DAG: Haemopoietic stem cell grafting for chronic granulocytic leukaemia: Clinical results and cytogenetic findings. Exp Hematol 10:1982.Google Scholar
  14. 14.
    Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD: Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 71:723–727, 1988.PubMedGoogle Scholar
  15. 15.
    Kessinger A, Armitage JO, Smith DM, Landmark JD, Bierman PJ, Weisenburger DD: High-dose therapy and autologous peripheral blood stem cell transplantation for patients with lymphoma. Blood 74:1260–1265, 1989.PubMedGoogle Scholar
  16. 16.
    Bitran JD, Williams SF, Moormeier J, Mick R: High-dose combination chemotherapy with thiotepa and autologous hematopoietic stem cell reinfusion in the treatment of patients with relapsed refractory lymphomas. Semin Oncol 17:39–42, 1990.PubMedGoogle Scholar
  17. 17.
    Williams SF, Bitran JD, Richards JM, DeChristopher PJ, Barker E, Conant J, Golomb HM, Orlina AR: Peripheral blood-derived stem cell collections for use in autologous transplantation after high dose chemotherapy: An alternative approach. Bone Marrow Transplant 5:129–133, 1990.PubMedGoogle Scholar
  18. 18.
    Lobo F, Kessinger A, Landmark JD, Smith DM, Weisenburger DD, Wigton RS, Armitage JO: Addition of peripheral blood stem cells collected without mobilization techniques to transplanted autologous bone marrow did not hasten marrow recovery following myelo-ablative therapy. Bone Marrow Transplant 3:389–392, 1991.Google Scholar
  19. 19.
    Richman CM, Weiner RS, Yankee RA: Increase in circulating stem cells following chemotherapy in man. Blood 47:1031–1039, 1976.PubMedGoogle Scholar
  20. 20.
    Henon P, Debecker A, Lepers M, Eisenmann JC, Kandel G, Dorr R, Selva J: Collection of circulating stem cells and their use for autograft in adults with acute lymphoblastic leukaemia. Nouv Rev Fr Hematol 30:229–235, 1988.PubMedGoogle Scholar
  21. 21.
    To LB, Dyson PG, Branford AL, Russell JA, Haylock DN, Ho JQK, Kimber RJ, Juttner CA: Peripheral blood stem cells collected in very early remission produce rapid and sustained autologous haemopoietic reconstitution in acute non-lymphoblastic leukaemia. Case Report. Bone Marrow Transplant 2:103–108, 1987.PubMedGoogle Scholar
  22. 22.
    Juttner CA, To LB, Ho JQK, Bardy PG, Dyson PG, Haylock DN, Kimber RJ: Early lympho-hemopoietic recovery after autografting using peripheral blood stem cells in acute non-lymphoblastic leukemia. Transplant Proc 20:40–42, 1988.PubMedGoogle Scholar
  23. 23.
    Körbling M, Dörken B, Ho AD, Pezzutto A, Hunstein W, Fliedner TM: Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt’s lymphoma. Concise report. Blood 67:529–532, 1986.PubMedGoogle Scholar
  24. 24.
    Gianni AM, Bregni M, Siena S, Villa S, Sciorelli GA, Ravagnani F, Pellegris G, Bonadonna G: Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells. A changing role for high dose chemo-radiotherapy? Hematol Oncol 7:139–148, 1989.PubMedGoogle Scholar
  25. 25.
    Bell AJ, Figes A, Oscier DG, Hamblin TJ: Peripheral blood stem cell autografts in the treatment of lymphoid malignancies: Initial experience in three patients. Br J Haematol 66:63–68, 1987.PubMedGoogle Scholar
  26. 26.
    Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ: Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan or supra-lethal chemoradiotherapy. Br J Haematol 61:739–745, 1985PubMedGoogle Scholar
  27. 27.
    To LB, Juttner CA: Peripheral blood stem cell autografting: A new therapeutic option for AML? Br J Haematol 66:285–288, 1987.PubMedGoogle Scholar
  28. 28.
    Juttner CA, To LB, Ho JQK, Thorp DL, Kimber RJ: Successful peripheral blood stem-cell autograft with a near-critical dose of myeloid progenitor cells in acute nonlymphoblastic leukaemia in relapse. Med J Aust 147:292–293, 1987.PubMedGoogle Scholar
  29. 29.
    Cline MJ, Golde DW: Mobilisation of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin. Exp Hematol 5:186, 1977.PubMedGoogle Scholar
  30. 30.
    Morra L, Ponassi A, Parodi CB, Caristo G, Bruzzi G, Sacchetti C: Mobilisation of colony forming cells (CFU-C) into the peripheral blood of man by hydrocortisone. Biomedicine 35:87, 1981.PubMedGoogle Scholar
  31. 31.
    Laporte JP, Douay L, Allieri A, Lopez M, Montbrun MCD, Mary JY, Giarratana MC, Isnard F, Najman A, Gorin NC: Expansion by folinic acid of the peripheral blood progenitor pool after chemotherapy: Its use in autografting in acute leukaemia. Br J Haematol 74:445–451, 1990.PubMedGoogle Scholar
  32. 32.
    Ross WM, Korbling M, Nothdurft W, Fliedner TM: The role of dextran sulfate in increasing the CFU-C concentration in dog blood. Proc Soc Exp Biol Med 157:301, 1978.PubMedGoogle Scholar
  33. 33.
    To LB, Roberts MM, Haylock DN, Dyson PG, Branford AL, Thorp D, Ho JQK, Dart GW, Harvoth N, Davy MLJ, Olweny CLM, Abdi E, Juttner CA: Comparison of hematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants. Bone Marrow Transplant 9:277–284, 1992.PubMedGoogle Scholar
  34. 34.
    Henon PR, Liang H, Beck-Wirth G, Eisenmann JC, Lepers M, Wunder E, Kandel G: Comparison of hematopoietic and immune recovery after autologous bone marrow or blood stem cell transplants. Bone Marrow Transplant 9:285–291, 1992.PubMedGoogle Scholar
  35. 35.
    Dührsen U, Villeval J-L, Boyd J, Kannourakis G, Morstyn G, Metcalf D: Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72:2074–2081, 1988.PubMedGoogle Scholar
  36. 36.
    Socinski MA, Elias A, Schnipper L, Cannistra SA, Antman KH, Griffin JD: Granulocyte-macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell compartment in man. Lancet 1:1192–1198, 1988.Google Scholar
  37. 37.
    Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM: Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor, Blood 76:2153–2158, 1990.PubMedGoogle Scholar
  38. 38.
    Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM: Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients: Enhancement by intravenous recombinant human granulocyte-macro-phage colony-stimulating factor. Blood 74:1905–1914, 1989.PubMedGoogle Scholar
  39. 39.
    Gianni AM, Siena S, Bregni M, Tarella C, Stern AC, Pileri A, Bonadonna G: Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation. Lancet 2:580–585, 1989.PubMedGoogle Scholar
  40. 40.
    Bensinger WI, Longin K, Appelbaum F, Rowley S, Weaver C, Lilleby K, Gooley T, Lynch M, Higano T, Klarnet J, Chauncey T, Storb R, Buckner CD: Peripheral blood stem cells (PBSCs) collected after recombinant granulocyte colony stimulating factor (rhG-CSF): An analysis of factors correlating with the tempo of engraftment after transplantation. Br J Haematol 87:825–831, 1994.PubMedGoogle Scholar
  41. 41.
    Pettengell R, Morgenstern GR, Woll PJ, Chang J, Rowlands M, Young R, Radford JA, Scharffe JH, Testa NG, Crowther D: Peripheral blood progenitor cell transplantation in lymphoma and leukemia using a single apheresis. Blood 82:3770–3777, 1993.PubMedGoogle Scholar
  42. 42.
    Bishop MR, Anderson JR, Jackson JD, Bierman PJ, Reed EC, Vose JM, Armitage JO, Warkentin PI, Kessinger A: High-dose therapy and peripheral blood progenitor cell transplantation: Effects of recombinant human granulocyte-macrophage colony-stimluating factor on the autograft. Blood 83:610–616, 1994.PubMedGoogle Scholar
  43. 43.
    Hohaus S, Goldschmidt H, Ehrhardt R, Haas R: Successful autografting following myelo-ablative conditioning therapy with blood stem cells mobilized by chemotherapy plus rhG-CSF. Exp Hematol 21:508–514, 1993.PubMedGoogle Scholar
  44. 44.
    Schwartzberg LS, Birch R, Hazelton B, Tauer KW, Lee P Jr, Altemose R, George C, Blanco R, Wittlin F, Cohen J, Muscato J, West WH: Peripheral blood stem cell mobilization by chemotherapy with and without recombinant human granulocyte colony-stimulating factor. Hematother 1:317–327, 1992.Google Scholar
  45. 45.
    Dreger P, Marquardt P, Haferlach T, Jacobs S, Mülverstedt T, Eckstein V, Suttorp M, Löffler H, Müller-Rucholtz W, Schmitz N: Effective mobilisation of peripheral blood progenitor cells with ‘Dexa-BEAM’ and G-CSF: Timing of harvesting and composition of the leukapheresis product. Br J Cancer 68:950–957, 1993.PubMedGoogle Scholar
  46. 46.
    Spencer V, Smith J, Kulkarni S, Petruska P, Broun G, Dunphy F, Martin T, Daniel F, Spitzer G: Does transplantation of a high number of CD34 cells predict more rapid engraftment following high-dose chemotherapy (abstr). Proc Am Soc Clin Oncol 11:131, 1992.Google Scholar
  47. 47.
    Dunphy F, Adkins D, Williams O, Petruska P, Brown G, Velasquez W, Bowers C, Daniel F, Spitzer G: In vivo hematopoietic progenitor expansion with GCSF (PRIMER) pre high-dose therapy (HDT) accelerates neutrophil (abstr). Blood 80,Supplement 1: 290a, 1992.Google Scholar
  48. 48.
    Spitzer G, Spencer V, Dunphy F, Kulkarni S, Petruska P, Velasquez W, Ruppel L, Adkins D: Are growth factors (GF) needed after peripheral blood stem cell (PBSC) transplantation? A randomized study to evaluate the question (abstr). Proc Am Soc Clin Oncol 12:467, 1993.Google Scholar
  49. 49.
    Till JE, McCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213, 1961.PubMedGoogle Scholar
  50. 50.
    Humphries RK, Eaves AC, Eaves CJ: Characterization of a primitive erythropoietic progenitor found in mouse marrow before and after several weeks in culture. Blood 53:746, 1979.PubMedGoogle Scholar
  51. 51.
    Baum CM, Weissman IL, Tsukamoto AS, Buckle A-M, Peault B: Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89:2804, 1992.PubMedGoogle Scholar
  52. 52.
    Elias AD, Ayash L, Anderson KC, Hunt M, Wheeler C, Schwartz G, Tepler I, Mazanet R, Lynch C, Pap S, Pelaez J, Reich E, Critchlow J, Demetri G, Bibbo J, Schnipper L, Griffin JD, Frei EHI, Antman K: Mobilization of peripheral blood progenitor cells by chemotherapy and granulocyte-macrophage colony-stimulating factor for hematologic support after high-dose intensification for breast cancer. Blood 79:3036–3044, 1992.PubMedGoogle Scholar
  53. 53.
    Bender JG, Williams SF, Myers S, Nottleman D, Lee WJ, Unverzagt KL, Walker D, To LB, Van Epps DE: Characterization of chemotherapy mobilized peripheral blood progenitor cells for use in autologous stem cell transplantation. Bone Marrow Transplant 10:281–285, 1992.PubMedGoogle Scholar
  54. 54.
    Kawano Y, Takaue Y, Watanabe T, Saito S-i, Abe T, Hirao A, Sato J, Ninomiya T, Suzue T, Koyama T, Shimokawa T, Yokobayashi A, Asano S, Masaoka T, Takaku F, Kuroda Y: Effects of progenitor cell dose and preleukapheresis use of human recombinant granulocyte colony-stimluating factor on the recovery of hematopoiesis after blood stem cell autografting in children. Exp Hematol 21:103–108, 1993.PubMedGoogle Scholar
  55. 55.
    Menichella G, Pierelli L, Foddai ML, Paoloni A, Vittori M, Serafini R, Benedetti P, Scambia G, Baiocchi G, Greggi S, Laureili G, Salerno G, Mancuso S, Manco G, Bizzi B: Autologous blood stem cell harvesting and transplantation in patients with advanced ovarian cancer. Br J Haematol 79:444–450, 1991.PubMedGoogle Scholar
  56. 56.
    Reid CDL, Kirk A, Muir J, Chanarin I: The recovery of circulating progenitor cells after chemotherapy in AML and ALL and its relation to the rate of bone marrow regeneration after aplasia. Br J Haematol 72:21–27, 1989.PubMedGoogle Scholar
  57. 57.
    Teshima T, Harada M, Takamatsu Y, Makino K, Inaba S, Akashi K, Kondo S, Tanaka T, Ishii E, Niho Y: Granulocyte colony-stimulating factor (G-CSF)-induced mobilization of circulating haemopoietic stem cells. Br J Haematol 84:570–573, 1993.PubMedGoogle Scholar
  58. 58.
    Khayat D, Weil M, Auclerc G, Thomas A, Baillet F, Housset, Rixe O, Antoine E, Nizri D, Bensfia S, Benhammouda A, Petit T, Soubrane CI: Clinical relevance of tumor regression (TR) in neoadjuvant (NEOADJ) chemotherapy (CHEMO) in breast cancer (BC) revisited (abstr). Proc Am Soc Clin Oncol 13:74, 1994.Google Scholar
  59. 59.
    Sutherland HJ, Eaves CJ, Lansdorp PM, Phillips GL, Hogge DE: Kinetics of committed and primitive blood progenitor mobilization after chemotherapy and growth factor treatment and their use in autotransplants. Blood 83:3808–3814, 1994.PubMedGoogle Scholar
  60. 60.
    Brice P, Marolleau JP, Dombret H, Lepage E, Baruchel A, Adam M, Miclea JM, Sitthy X, Gisselbrecht C: Autologous peripheral blood stem cell transplantation after high dose therapy in patients with advanced lymphomas. Bone Marrow Transplant 9:337–342, 1992.PubMedGoogle Scholar
  61. 61.
    Siena S, Bregni M, Brando B, Belli N, Ravagnani F, Gandola L, Stern AC, Lansdorp PM, Bonadonna G, Gianni AM: Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Blood 77: 400–409, 1991.PubMedGoogle Scholar
  62. 62.
    Serke S, Säuberlich S, Huhn D: Multiparameter flow-cytometrical quantitation of circulating CD34+-cells: Correlation to the quantitation of circulating haemopoietic progenitor cells by in vitro colony-assay. Br J Haematol 77:453–459, 1991.PubMedGoogle Scholar
  63. 63.
    Fritsch G, Emminger W, Buchinger P, Printz D, Gadner H: CD-34 positive cell proportions in peripheral blood correlate with colony-forming capacity. Exp Hematol 19:1079–1083, 1991.PubMedGoogle Scholar
  64. 64.
    Siena S, Bregni M, Gianni AM: Estimation of peripheral blood CD34+ cells for autologous transplantation in cancer patients. Exp Hematol 21:203–205, 1993.PubMedGoogle Scholar
  65. 65.
    Schwartzberg L, Birch R, Blanco R, Wittlin F, Muscato J, Tauer K, Hazelton B, West W: Rapid and sustained hematopoietic reconstitution by peripheral blood stem cell infusion alone following high-dose chemotherapy. Bone Marrow Transplant 11:369–374, 1993.PubMedGoogle Scholar
  66. 66.
    Juttner CA, To LB, Haylock DN, Dyson PG, Sage RE, Dale BM, Shepherd M: The threshold effect in peripheral blood stem cell autografting — differences between acute myeloid leukaemia and non’ stem cell diseases’ (abstr). Experimental Hematology 17:650, 1989.Google Scholar
  67. 67.
    Mortimer J, Hendricks D, Goodnough LT, Zutter M, Fears C, Brown RA: Pheresis of peripheral blood progenitor cells directed by CD34 counts (abstr). Proc Am Soc Clin Oncol 12:467, 1992.Google Scholar
  68. 68.
    Lasky LC: The blood bank as a source of hematopoietic stem cells. In Transfusion Medicine: Recent Technological Advances. New York: Alan R. Liss, 1986, pp 199–225.Google Scholar
  69. 69.
    Lasky LC, Bostrom B, Smith J, Moss TJ, Ramsay NKC: Clinical collection and use of peripheral blood stem cells in pediatric patients. Transplantation 47:613–616, 1989.PubMedGoogle Scholar
  70. 70.
    Rowley SD, Bensinger WI, Gooley TA, Buckner CD: The effect of cell concentration on bone marrow and peripheral blood stem cell cryopreservation. Blood 83:2731–2736, 1994.PubMedGoogle Scholar
  71. 71.
    Takaue Y, Abe T, Kawano Y, Suzue T, Saito S, Hirao A, Sato J, Makimoto A, Kawahito M, Watanabe T, Shimokawa T, Kuroda Y: Comparative analysis of engraftment after cryopreservation of peripheral blood stem cell autografts by controlled-versus uncontrolled-rate methods. Bone Marrow Transplant 13:801–804, 1994.PubMedGoogle Scholar
  72. 72.
    Bitran J, White L, Okuno T, Martinec J, Samuels B, Klein L: Mobilization of early hematopoietic progenitors after high dose cyclophosphamide alone and cyclophosphamide + thiotepa (abstr). Proc Am Soc Clin Oncol 442, 1993.Google Scholar
  73. 73.
    Bengala C, Fennelly D, Shapiro E, Schneider J, Reich L, Moore MAS, Norton L, Crown J: Taxol (TXL) in combination with cyclophosphamide (CTX) and G-CSF can improve the mobilization of peripheral blood progenitors cells (PBPCs) in untreated locally advanced ovarian cancer: Preliminary report (abstr). Blood 82,Suppl. 1:82a, 1993.Google Scholar
  74. 74.
    Crown J, Fennelly D, Schneider J, Hakes T, Bengala C, McKenzie M, Reich L, Barakat R, Curtin J, Spriggs D, Hoskins W, Norton L: Escalating dose taxol (T) + high-dose (HD) cyclophosphamide (C)/G-CSF (G) as induction and to mobilize peripheral blood progenitors (PBP) for use as rescue following multiple courses of HD carboplatin (P)/C: A phase I trial in ovarian cancer patients (PTS) (abstr). Proc Am Soc Clin Oncol 262, 1994.Google Scholar
  75. 75.
    Sheridan WP, Begley CG, Juttner CA, Szer J, To LB, Maher D, McGrath KM, Morstyn G, Fox RM: Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 1:640–644, 1992.Google Scholar
  76. 76.
    Bensinger W, Singer J, Appelbaum F, Lilleby K, Longin K, Rowley S, Clarke E, Clift R, Hansen J, Shields T, Storb R, Weaver C, Weiden P, Buckner CD: Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor. Blood 81:3158–3163, 1993.PubMedGoogle Scholar
  77. 77.
    Haas R, Ho AD, Bredthauer U, Cayeux S, Egerer G, Knauf W, Hunstein W: Successful autologous transplantation of blood stem cells mobilized with recombinant human granulocyte-macrophage colony-stimulating factor. Exp Hematol 18:94–98, 1990.PubMedGoogle Scholar
  78. 78.
    Peters WP, Rosner G, Ross M, Vredenburg J, Meisenberg B, Gilbert C, Kurtzberg J: Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy. Blood 81:1709–1719, 1993.PubMedGoogle Scholar
  79. 79.
    Tane L, Law P, Maruyama M, Young D, Burgess J, Terstappen L, Corringham R, Ho A: Harvesting and enrichment of hematopoietic stem cells mobilized into the peripheral blood of normal donors by GCSF or GMCSF: Potential role in allogeneic marrow transplantation (abstr). Proc Am Soc Clin Oncol 13:440, 1994.Google Scholar
  80. 80.
    Glaspy J, McNiece I, LeMaistre F, Menchaca D, Briddell R, Lill M, Jones R, Tami J, Morstyn G, Brown S, Shpall EJ: Effects of stem cell factor (rhSCF) and filgrastim (rhG-CSF) on mobilization of peripheral blood progenitor cells (PBPC) and on hematological recovery posttransplant: early results from a phase I/II study (abstr). Proc Am Soc Clin Oncol 13:68, 1994.Google Scholar
  81. 81.
    Bolwell B, Fishleder A, Baucco P, Yanssens T, Burwell R, Lichtin A, Andresen S, Koo A, Green R: GCSF primed peripheral blood progenitor cells (PBPC) enhances neutrophil and platelet engraftment in autologous bone marrow transplantation (ABMT) (abstr). Blood 80,Suppl. 1:340a, 1992.Google Scholar
  82. 82.
    Reding D, Lappe K, Huber J: A breast health education intervention for rural public health professionals (abstr). Proc Am Soc Clin Oncol 13:92, 1994.Google Scholar
  83. 83.
    Sheridan W, Begley G, Juttner C, de Luca E, To LB, Szer J, Maher D, Watson D, Grigg A, Cebon J, Morstyn G, McGrath K, Green M, Tornita D, Hoffman E, Fox RM: Effect of different doses and schedules of R-methug-CSF (Filgrastim) on mononuclear cell and PBPC collections and haematopoietic recovery after high dose chemotherapy (HDC) and infusion of R-methug-CSF mobilized peripheral blood progenitor cells (PBPC) without bone marrow (abstr). Blood 80,Suppl. 1:331a, 1992.Google Scholar
  84. 84.
    Spitzer G, Dunphy F, Adkins D, Bowers C, Petruska P, Velasquez W, Brown G, Kronmueller N, Niemeyer R: Are combinations of growth factors (GF) superior to G-CSF alone for optimal mobilization of peripheral blood stem cells (PBSC)? A randomized study of G-CSF vs. G-CSF + GM-CSF for PBSC mobilization to evaluate the question (abstr). Proc Am Soc Clin Oncol 13:455, 1994.Google Scholar
  85. 85.
    Cantin G, Marchand-Laroche D, Bouchard M-M, Leblond P-F: Blood-derived stem cell collection in acute nonlymphoblastic leukemia: Predictive factors for a good yield. Exp Hematol 17:991–996, 1989.PubMedGoogle Scholar
  86. 86.
    Haas R, Möhle R, Frühauf S, Goldschmidt H, Witt B, Flentje M, Wannenmacher M, Hunstein W: Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma. Blood 83:3787–3794, 1994.PubMedGoogle Scholar
  87. 87.
    Brugger W, Bross K, Frisch J, Dem P, Weber B, Mertelsmann R, Kanz L: Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin. Blood 79:1193–1200, 1992.PubMedGoogle Scholar
  88. 88.
    Advani R, Chao NJ, Horning SJ, Blume KG, Ahn DK, Lamborn KR, Fleming NC, Bonnern EM, Greenberg PL: Ganulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjunct to autologous hemopoietic stem cell transplantation for lymphoma. Ann Intern Med 116:183–189, 1992.PubMedGoogle Scholar
  89. 89.
    Brenner MK, Rill DR, Holladay MS, Heslop HE, Moen RC, Buschle M, Krance RA, Santana VM, Anderson WF, Ihle JN: Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet 342:1134–1137, 1993.PubMedGoogle Scholar
  90. 90.
    To LB, Russell J, Moore S, Juttner CA: The level of leukemic cells in very early remission of acute non-lymphoblastic leukemia (abstr). Exp Hematol 14:472, 1986.Google Scholar
  91. 91.
    Ross AA, Cooper BW, Lazarus HM, Mackay W, Moss TJ, Ciobanu N, Tallman MS, Kennedy MJ, Davidson NE, Sweet D, Winter C, Akard L, Jansen J, Copelan E, Meagher RC, Herzig RH, Klumpp TR, Kahn DG, Warner NE: Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immuno-cytochemical and clonogenic assay techniques. Blood 82:2605–2610, 1993.PubMedGoogle Scholar
  92. 92.
    Brugger W, Bross KJ, Glatt M, Weber F, Mertelsmann R, Kanz L: Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83:636–640, 1994.PubMedGoogle Scholar
  93. 93.
    Gribben JG, Neuberg D, Barber M, Moore J, Pesek KW, Freedman AS, Nadler LM: Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow. Blood 83:3800–3807, 1994.PubMedGoogle Scholar
  94. 94.
    Dockhorn-Dwomiczak B, Schäfer K-L, Dantcheva R, van Valen F, Kraut K, St. Burdach, Böcker W, Jürgens H: Evaluation of peripheral blood, bone marrow and stem cell grafts of Ewing’s sarcoma patients for residual tumor cells by detection of EWS/FLI-1 fusion transcripts (abstr). Proc Am Soc Clin Oncol 13:417, 1994.Google Scholar
  95. 95.
    Shpall EJ, Jones RB, Bearman SI, Franklin WA, Archer PG, Curiel T, Bitter M, Claman HN, Stemmer SM, Purdy M, Myers SE, Hami L, Taffs S, Heimfeld S, Hallogan J, Berenson RJ: Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: Influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment. J Clin Oncol 12:28–36, 1994.PubMedGoogle Scholar
  96. 96.
    Vose JM, Anderson JR, Kessinger A, Bierman PJ, Coccia P, Reed EC, Gordon B, Armitage JO: High-dose chemotherapy and autologous hematopoietic stem-cell transplantation for aggressive non-Hodgkin’s lymphoma. J Clin Oncol 11:1846–1851, 1993.PubMedGoogle Scholar
  97. 97.
    Crown J, Raptis G, Vahdat L, Fennelly D, Hamilton N, Hudis C, Gilewski T, Seidman A, Reich L, Norton L: Rapid administration of sequential high dose (HD) cyclopho-sphamide (CPA), melphalan (M), thiotepa (TT) supported by filgrastim (G) + peripheral blood progenitors (PBP) in patients (PTS) with metastatic breast cancer (MBC): A novel and very active treatment strategy (abstr). Proc Am Soc Clin Oncol 13:110, 1994.Google Scholar
  98. 98.
    Bokemeyer C, Schmoll H-J, Arsenlev L: Treatment of advanced testicular cancer with dose intensified chemotherapy plus GM-CSF alone or G-CSF and sequential harvesting and reinfusion of peripheral blood stem cells (PBSC) (abstr). Proc Am Soc Clin Oncol 13:236, 1994.Google Scholar
  99. 99.
    Ghalie R, Richman C, Bender J, McLeod B, Lee W, Manson S, Van Epps D, Valentino L, Feingold J, Pruett J, Brown S, Kaizer H: Tanden transplants using peripheral blood progenitor cells (PBPC) mobilized with chemotherapy and filgrastim (G-CSF) (abstr). Proc Am Soc Clin Oncol 13:435, 1994.Google Scholar
  100. 100.
    Carella AM, Podesta M, Frassoni F, Pungolino E, Pollicardo N, Raffo MR, Ferrero R, Benvenuto F, Figari O, Giordano D, Lercari G, Carlier P, Valbonesi M, Vitale V, Parodi M, Gallamini A, Saglio G, Marmont A: Selective overshoot of Ph-negative blood hemo-poietic cells after intensive idarubicin-containing regimen and their repopulating capacity after reinfusion (abstr). Stem Cells 11(Suppl 3):67–72, 1993.PubMedGoogle Scholar
  101. 101.
    Vellekoop L, Zander AR, Kantarjian HM, Jagannath S, Hester JP, Trujillo J, McCredie KB, Zagars G, Spitzer G, Dicke KA: Piperazinedione, total body irradiation, and autologous bone marrow transplantation in chronic myelogenous leukemia. J Clin Oncol 4:906–911, 1986.PubMedGoogle Scholar
  102. 102.
    Karp DD, Parker LM, Binder N, Tantravahi R, Smith BR, Ervin TJ, Canellos GP: Treatment of the blastic transformation of chronic granulocytic leukemia using high dose BCNU chemotherapy and cryopreserved autologous peripheral blood stem cells. Am J Hematol 18:243–249, 1985.PubMedGoogle Scholar
  103. 103.
    Jagannath S, Vesole DH, Glenn L, Crowley J, Barlogie B: Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. Blood 80:1666–1672, 1992.PubMedGoogle Scholar
  104. 104.
    Fermand J-P, Levy Y, Gerota J, Benbunan M, Cosset J-M, Castaigne S, Seligmann M, Brouet J-C: Treatment of multiple myeloma by high dose chemotherapy, total body irradiation and autologous blood stem cell autograft. Nouv Rev Fr Hematol 31:85–87, 1989.PubMedGoogle Scholar
  105. 105.
    Vescio R, Hong C, Cao J, Kim A, Schiller G, Lichtenstein A, Berenson R, Berenson J: The hematopoietic stem cell antigen, CD34, is not expressed on the malignant cells in multiple myeloma (abstr). Proc Am Soc Clin Oncol 13:408, 1994.Google Scholar
  106. 106.
    Bensinger WI, Price TH, Dale DC, Appelbaum FR, Clift R, Lilleby K, Williams B, Storb R, Thomas ED, Buckner CD: The effects of daily recombinant human granulocyte colony stimulating factor administration on normal granulocyte donors undergoing leukapheresis. Blood 81:1883–1888, 1993.PubMedGoogle Scholar
  107. 107.
    Weaver CH, Buckner CD, Longin K, Appelbaum FR, Rowley S, Lilleby K, Miser J, Storb R, Hansen JA, Bensinger W: Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor. Blood 82:1981–1984, 1993.PubMedGoogle Scholar
  108. 108.
    Weaver CH, Longin K, Buckner CD, Bensinger W: Lymphocyte content in peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor. Bone Marrow Transplant 13:411–415, 1994.PubMedGoogle Scholar
  109. 109.
    Kessinger A, Smith DM, Strandjord SE, Landmark JD, Dooley DC, Law P, Coccia PF, Warkentin PI, Weisenburger DD, Armitage JO: Allogeneic transplantation of blood-derived, T cell-depleted hemopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia. Bone Marrow Transplant 4:643–646, 1989.PubMedGoogle Scholar
  110. 110.
    Russell NH, Hunter A, Rogers S, Hanley J, Anderson D: Peripheral blood stem cells as an alternative to marrow for allogeneic transplantation. Lancet 341:1482, 1993.PubMedGoogle Scholar
  111. 111.
    Schmitz N, Dreger P, Suttorp M, Rohwedder E, Haferlach T, Jacobs S, Löffler H: Transplantation of allogeneic filgrastim (G-CSF) mobilised peripheral blood progenitor cells (PBPC) after myeloablative therapy (abstr). Br J Haematol 87(Suppl 1):44, 1994.Google Scholar
  112. 112.
    Dreger P, Hafurlach T, Eckstein V, Jacues S, Suttorp M, Löffler H, Müller-Richmoltz W, Schmitz N: G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: Safety, kinetics of mobilization, and composition of the graft. Br J Haematol 87:609–613, 1994.PubMedGoogle Scholar
  113. 113.
    Dreger P, Viehmann K, Steinmann J, Eckstein V, Müller-Ruchholtz W, Löffler H, Schmitz N: G-CSF-mobilised peripheral blood progenitor cells for allogeneic transplantation: Comparison of T cell depletion strategies using different CD34+ selection systems or CAMPATH-1. Exp Hematol 23:147–154, 1995.PubMedGoogle Scholar
  114. 114.
    Chao NJ, Schriber JR, Grimes K, Long GD, Negrin RS, Raimondi CM, Horning SJ, Brown SL, Miller L, Blume KG: Granulocyte colony-stimulating factor ‘mobilized’ peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy. Blood 81:2031–2035, 1993.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1995

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  • William Bensinger

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