Interleukin-2 in Bone Marrow Transplantation

  • Udit N. Verma
  • Bishan S. Charak
  • Chitra Rajagopal
  • Amitabha Mazumder
Part of the Cancer Treatment and Research book series (CTAR, volume 76)


Interleukin 21 (IL-2) is a 15 kD protein that was initially known as T-cell growth factor [1], IL-2 stimulates the proliferation of T cells both in vitro and in vivo. Incubation of lymphocytes with IL-2 in vitro results in the generation of cells referred to as lymphokine activated killer (LAK) cells, which lyse fresh noncultured tumor cells in a histocompatibility unrestricted manner [2–4]. LAK cells show killing effects both in vitro and in vivo of a wide variety of tumors [2–4]. Recent studies [5,6] have shown that LAK cells are comprised of T cells as well as natural killer (NK) cells. Other cells, such as macrophages, probably also play a role in regulating the generation of LAK cells.


Acute Myeloid Leukemia Graft Versus Host Disease Lymphokine Activate Killer Lymphokine Activate Killer Cell Cytotoxic Effector Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Udit N. Verma
  • Bishan S. Charak
  • Chitra Rajagopal
  • Amitabha Mazumder

There are no affiliations available

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