The P2Z Receptor and Its Regulation of Macrophage Function

  • Francesco Di Virgilio
  • Davide Ferrari
  • Maddalena Munerati
  • Simonetta Falzoni
  • Martin Villalba
  • Vincenzo Bronte
  • Annalisa Zambon
  • Paola Zanovello
  • Thomas H. Steinberg


In 1967 the late Zanvil A. Cohn reported that adenine nucleotides had striking effects on the morphology and pinocytic activity of mouse macrophages [1]. These early studies were followed by the demonstration by Sung et al. that extracellular ATP (ATPe) caused plasma membrane depolarization, increased intracellular Ca2+ ([Ca2+]i), and inhibition of Fc receptor-mediated phagocytosis [2]. These intriguing effects remained unexplained until the work by Steinberg and Silverstein, who started a thorough investigation of the mechanism of macrophage responses to extracellular nucleotides, ATP in particular [3,4].


Mouse Macrophage J774 Macrophage Plasma Membrane Depolarization J774 Mouse Macrophage Pinocytic Activity 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Francesco Di Virgilio
  • Davide Ferrari
  • Maddalena Munerati
  • Simonetta Falzoni
  • Martin Villalba
  • Vincenzo Bronte
  • Annalisa Zambon
  • Paola Zanovello
  • Thomas H. Steinberg

There are no affiliations available

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