The P2Z Receptor and Its Regulation of Macrophage Function
In 1967 the late Zanvil A. Cohn reported that adenine nucleotides had striking effects on the morphology and pinocytic activity of mouse macrophages . These early studies were followed by the demonstration by Sung et al. that extracellular ATP (ATPe) caused plasma membrane depolarization, increased intracellular Ca2+ ([Ca2+]i), and inhibition of Fc receptor-mediated phagocytosis . These intriguing effects remained unexplained until the work by Steinberg and Silverstein, who started a thorough investigation of the mechanism of macrophage responses to extracellular nucleotides, ATP in particular [3,4].
KeywordsMouse Macrophage J774 Macrophage Plasma Membrane Depolarization J774 Mouse Macrophage Pinocytic Activity
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