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The P2Z Receptor and Its Regulation of Macrophage Function

  • Francesco Di Virgilio
  • Davide Ferrari
  • Maddalena Munerati
  • Simonetta Falzoni
  • Martin Villalba
  • Vincenzo Bronte
  • Annalisa Zambon
  • Paola Zanovello
  • Thomas H. Steinberg

Abstract

In 1967 the late Zanvil A. Cohn reported that adenine nucleotides had striking effects on the morphology and pinocytic activity of mouse macrophages [1]. These early studies were followed by the demonstration by Sung et al. that extracellular ATP (ATPe) caused plasma membrane depolarization, increased intracellular Ca2+ ([Ca2+]i), and inhibition of Fc receptor-mediated phagocytosis [2]. These intriguing effects remained unexplained until the work by Steinberg and Silverstein, who started a thorough investigation of the mechanism of macrophage responses to extracellular nucleotides, ATP in particular [3,4].

Keywords

Mouse Macrophage J774 Macrophage Plasma Membrane Depolarization J774 Mouse Macrophage Pinocytic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Francesco Di Virgilio
  • Davide Ferrari
  • Maddalena Munerati
  • Simonetta Falzoni
  • Martin Villalba
  • Vincenzo Bronte
  • Annalisa Zambon
  • Paola Zanovello
  • Thomas H. Steinberg

There are no affiliations available

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