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Coronary Adenosine Receptors: Subtypes, Localization, and Function

  • S. Jamal Mustafa
  • Ravi Marala
  • Worku Abebe
  • Neil Jeansonne
  • Hammed Olanrewaju
  • Tahir Hussain

Abstract

Despite the historic observations of Drury and Szent Gyorgyi in 1929 [1] that adenosine causes coronary vasodilation, hypotension, and bradycardia, it was not until 30 years later that Berne [2] proposed the adenosine hypothesis for the metabolic regulation of coronary blood flow. A large body of literature has been accumulated on the cardiovascular actions of adenosine since that time.

Keywords

Adenosine Receptor Human Coronary Artery Porcine Coronary Artery Arterial Ring Adenosine Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Drury AN, Szent-Gyorgyi A (1929) The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol 68:213–237.PubMedGoogle Scholar
  2. 2.
    Berne RM (1963) Cardiac nucleotides in hypoxia: A possible role in regulation of coronary blood flow. Am J Physiol 204:317–322.PubMedGoogle Scholar
  3. 3.
    Olsson RA, Davis CJ, Khouri EM, Patterson RE (1976) Evidence for an adenosine receptor on the surface of dog coronary myocytes. Circ Res 39:93–98.PubMedCrossRefGoogle Scholar
  4. 4.
    Cushing DJ, Brown GL, Sabouni MH, Mustafa SJ (1991) Adenosine-receptor-mediated coronary artery relaxation and cyclic nucleotide production. Am J Physiol 261:H343–H348.PubMedGoogle Scholar
  5. 5.
    Sabouni MH, Hussain T, Cushing DJ, Mustafa SJ (1991) G-proteins subserve relaxation mediated by adenosine receptors in human coronary artery. J Cardiovasc Pharmacol 18:696–702.PubMedCrossRefGoogle Scholar
  6. 6.
    Hussain T, Mustafa SJ (1992) Effects of adenosine analogs on cholera toxin induced ADP-ribosylation of G-proteins in coronary artery. Am J Physiol 262:H875–H879.PubMedGoogle Scholar
  7. 7.
    Ramagopal MV, Chitwood R, Mustafa SJ (1988) Evidence for an A2 adenosine receptor in human coronary arteries. Eur J Pharmacol 151: 483–486.PubMedCrossRefGoogle Scholar
  8. 8.
    Sabouni MH, Mustafa SJ (1989) Effects of adenosine analogs on phasic contractions in human coronary artery. Eur J Pharmacol 168:271–276.PubMedCrossRefGoogle Scholar
  9. 9.
    Sabouni MH, Ramagopal MV, Mustafa SJ (1990) Relaxation by adenosine and its analogs in potassium contracted human coronary arteries. Naunyn Schmiedbergs Arch Pharmacol 341: 388–390.CrossRefGoogle Scholar
  10. 10.
    Makujina S, Sabouni MH, Bhatia S, Douglas FL, Mustafa SJ (1992) Vasodilatory effects of adenosine A2 receptor agonists CGS 21680 and CGS 22492 in human vasculature. Eur J Pharm 221:243–247.CrossRefGoogle Scholar
  11. 11.
    Mustafa SJ (1980) Cellular and molecular mechanism(s) of coronary flow regulation by adenosine. Mol Cell Biochem 31:67–87.PubMedCrossRefGoogle Scholar
  12. 12.
    Cushing DJ, Mustafa SJ (1991) Historical perspective-Adenosine. In Phillis JW (ed.), Adenosine and Adenine Nucleotides as Regulators of Cellular Function. Boca Raton, FL: CRC Press, pp. 3–13.Google Scholar
  13. 13.
    Linden J, Prater MR, Tucker A, Thompson RD, Olsson RA (1992) 125I-APE, a new and improved radioligand that binds selectively to native and recombinant adenosine A2a receptors (abstr). Int J Purine Pyrimidine Res 3:86.Google Scholar
  14. 14.
    Cornfield LJ, Hu S, Hurt SD, Sills MA (1992) [3H]2-phenylaminoadenosine ([3H]CV- 1808) labels a novel adenosine receptor in rat brain. J Pharmacol Exp Ther 263:552–561.PubMedGoogle Scholar
  15. 15.
    Makujina SR, Olanrewaju HA, Mustafa SJ (1994) Evidence against the involvement of ATP-sensitive K+ channels in adenosine A2 receptor-mediated vasorelaxation. Am J Physiol 267:H716–H724.PubMedGoogle Scholar
  16. 16.
    Luthin DR, Linden J (1994) Temperature-dependent binding of [3H]CV 1808: Mimicry of “A4” binding in COS cells expressing only recombinant A2a adenosine receptors (abstr). Drug Dev Res 31:292.Google Scholar
  17. 17.
    Hussain T, Mustafa SJ (1993) An in vitro pharmacological model in coronary smooth muscle. J Pharmacol Toxicol Methods 30: 111–115.PubMedCrossRefGoogle Scholar
  18. 18.
    Hussain T, Mustafa SJ (1993) Regulation of adenosine receptor system in coronary artery: Functional studies and cAMP. Am J Physiol 264 (Heart Circ Physiol 33):H441–H447.PubMedGoogle Scholar
  19. 19.
    Hussain T, Mustafa SJ (1994) Regulation of G proteins coupled to adenosine receptors in coronary artery. Am J Physiol 266 (Heart Circ Physiol 35):H1273–H1279.PubMedGoogle Scholar
  20. 20.
    Abebe W, Makujina S, Mustafa SJ (1994) Adenosine receptor-mediated relaxation of porcine coronary artery in presence and absence of endothelium. Am J Physiol 266:H2018—H2025.PubMedGoogle Scholar
  21. 21.
    Vials A, Burnstock G (1993) A2-purinoceptormediated relaxation in the guinea pig coronary vascular: A role for nitric oxide. Br J Pharmacol 109:424–429.PubMedCrossRefGoogle Scholar
  22. 22.
    Newman WH, Becker BF, Heirer H, Nees S, Gerlch E (1988) Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: Studies in isolated guinea pig hearts. Pflügers Arch 413:1–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Sabouni MH, Ramagopal MV, Mustafa SJ (1989) Roles of calcium and the endothelium in the relaxation produced by 5’-N-ethylcarboxamido-adenosine (NECA). Eur J Pharmacol 166:311–314.PubMedCrossRefGoogle Scholar
  24. 24.
    Olanrewaju HA, Hargittai PT, Lieberman EM, Mustafa SJ (1994) Endothelium-dependent and independent hyperpolarization by adenosine and its analogs in porcine coronary artery. J Cardiovasc Pharmacol, in press.Google Scholar
  25. 25.
    Feleton M, Vanhoutte PM (1988) Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 93:515–524.CrossRefGoogle Scholar
  26. 26.
    Mustafa SJ, Askar A (1985) Evidence suggesting a Ra-type adenosine receptor in bovine coronary arteries. J Pharmacol Exp Ther 232: 49–56.PubMedGoogle Scholar
  27. 27.
    Merkel LA, Lappe RW, Rivera LM, Cox LM, Perrone MH (1992) Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: Involvement of potassium channels. J Pharmacol Exp Ther 266:437–443.Google Scholar
  28. 28.
    Merkel LA, Rivera LM, Colussi DJ, Perrone MH (1991) Protein kinase C and vascular smooth muscle contractility: Effects of inhibitors and down-regulation. J Pharmacol Exp Ther 257: 134–140.PubMedGoogle Scholar
  29. 29.
    Marala RB, Ways K, Mustafa SJ (1993) 2Chloroadenosine prevents phorbol ester-induced depletion of protein kinase C in porcine coronary artery. Am J Physiol 264 (Heart and Circ Physiol 33):H1465–1471.PubMedGoogle Scholar
  30. 30.
    Young S, Parker PJ, Ullrich A, Stabel S (1987) Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem J 244: 775–779.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. Jamal Mustafa
  • Ravi Marala
  • Worku Abebe
  • Neil Jeansonne
  • Hammed Olanrewaju
  • Tahir Hussain

There are no affiliations available

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