Desensitization of A1 Adenosine Receptors

  • Edmund Hoppe
  • Martin J. Lohse


It is well known that exposure of sensitive cells to receptor agonists can cause a progressive reduction in their capacity to respond to this and related agonists. This phenomenon has been observed with cells expressing receptors from different superfamilies, and has been termed desensitization, refractoriness,tolerance, or tachyphylaxis [1]. The mechanisms responsible for this phenomenon have been studied extensively in cells that synthesize cyclic AMP in response to beta-adrenergic agonists. Exposure of such cells to isoproterenol or similar drugs may result in receptor uncoupling, receptor sequestration, and ultimately, in downregulation of receptors, resulting in a decline in the actual number of receptors [2].


Adenylyl Cyclase Adenosine Receptor cAMP Accumulation Adenylate Cyclase System Heterologous Desensitization 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Edmund Hoppe
  • Martin J. Lohse

There are no affiliations available

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